Medicinal chemistry
The latest chemistry news and research on medicinal chemistry including drug discovery, clinical trials, toxicology and science of disease, from the Royal Society of Chemistry's magazine, Chemistry World
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ResearchWorld first for clinical trial of skin patch to monitor therapeutic drugs in real time
Sensor could soon help doctors to prevent overdoses of drugs
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OpinionIs it cold in here?
Labs in Delhi, Aberdeen and Arizona will have different ideas of ‘room temperature’
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NewsIn 2023, the UK was the first country to approve a Crispr therapy. How’s it doing?
Disconnect exists between the media hype around gene-editing treatment and the reality for patients
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OpinionCrispr therapies will change medicine but there will be challenges along the way
The first treatments making use of Crispr gene editing may suffer some early hiccups
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FeatureThe toxic chemistry behind skin bleaching products
The global skin-lightening market is worth over $10 billion and growing, but the unregulated products driving it contain dangerous chemicals linked to serious health risks. Zahra Khan speaks to the scientists and advocates trying to fix the problem
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ResearchAI tool dramatically reduces computing power needed to find protein-binding molecules
New protocol is up to 10 million times faster than current docking-based methods
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NewsNew £50 million centre aims to shake up clinical trials in the UK
Initiative should speed up testing of new medicines
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OpinionAn airborne exposure route for a serious kidney disease
Linking Aristolochia plants to aristolochic acid nephropathy
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ResearchCrystal structure prediction reaches new heights with axitinib
Computational strategy predicts complex polymorphs and distinguishes salts from co-crystals
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BusinessUK agrees higher drug prices to secure zero-tariff deal with US
NHS could pay up to 25% more for innovative drugs, but exports will be tariff free for three years
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OpinionWhat’s on your lab technology wish list?
Once-magical tools are now mundane. What will the next miracles be?
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ResearchRevived claims that antibiotics don’t kill bacteria with reactive oxygen prove controversial
Researchers say that multiple lines of evidence for hypothesis have now been undermined
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OpinionInhaler propellant switch is worth the effort
Memories of a year spent testing new inhaler valve designs
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NewsCould Crispr cure HIV?
The first gene-editing therapies for HIV/Aids are entering trials but the virus is proving once again that it is a master at evading eradication
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ResearchCharge-switching polymer could hold the key to needle-free insulin gel
Animal tests reveal zwitterionic polymer can transport insulin through skin and regulate blood glucose
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OpinionA robotic helping hand
Mechanical labmates are making huge progress, but there are still big challenges to overcome
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ResearchCryo-EM snapshots reveal insight into how opioids activate their receptor
Insights from structural images could help design new opioids and antidotes to them
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FeatureOne medical inhaler can have the impact of 30kg of carbon dioxide
Propellants in asthma inhalers produce greenhouse gas emissions equivalent to driving 200 miles, yet most healthcare systems overlook this climate impact. New low-carbon alternatives are in development, Andy Extance reports, but barriers remain
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ResearchAI-designed antibodies target antigens with atomic precision
Epitope-binding proteins designed from scratch by generative AI model
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ResearchAI cut development time of antibiotic that spares gut-friendly bacteria by two years
Animal tests show promise to target invasive strain of E. coli but approval for use in humans is still years away