Biology – Page 18
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ResearchNeural network scours vast chemical space to design drug-delivering peptides
Oligonucleotide drug activity boosted 50-fold with peptide designed by machine learning algorithm
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ResearchMirror image enzyme constructs longest ever mirror DNA strand
Since chirally inverted DNA is more stable than its natural counterpart, it can be used to encode secret messages
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ResearchThere was more than simple oxygen depletion to ancient mass extinction event
Thallium isotopes reveal that rapid swings in ocean oxygenation preceded the events that wiped out 90% of species 250 million years ago
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NewsMachine learning delivers ‘human genome’ moment for proteins
Protein structure prediction tools AlphaFold and RoseTTAFold take the latest steps towards maturity and make their software open source
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ResearchEnigmatic DNA dubbed ‘Borgs’ discovered in methane-metabolising microbes
The large nucleic acid structures may help bacteria play a role in regulating global methane
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ResearchSnake extract used to speed up haemostasis in new bioadhesive
Hydrogel-based bioadhesive could be suitable for arterial injuries
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ResearchIndividual cell’s energy metabolism caught on camera for the first time
Combining machine learning with fluorescence imaging provides new insight in glycolysis and might help with development of new therapies for cancer
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BusinessEngineering microbes to degrade contaminants
Allonnia is using synthetic biology to tackle major environmental challenges like PFASs, metals and plastic waste
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ResearchElectrochemical DNA on a chip sensor detects bacterial urinary tract infections faster
Synthetic nucleic acid probes combine with tiny star-shaped electrodes tests for bacteria in less than an hour
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ResearchMolecular machines talk to living cells for the first time
Artificial molecular motors gently pull on cells’ membrane receptors to trigger a biochemical response
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OpinionOpening up a cellular black box
Working out how biomolecular condensates work may reveal a lot about the success or failure of different drugs
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ResearchProtein-shaped sweets help students understand complex molecular structures
Edible protein models that can be identified by mouth could make chemistry education more inclusive to blind and visually impaired students
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OpinionMabel FitzGerald and the mystery of oxygen sensing
Katharine Sanderson celebrates the tenacious and brilliant researcher who came tantalizingly close to describing oxygen sensing, a concept that earned the Nobel prize over 100 years later
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ResearchQuantum chemical reaction behind birds’ internal compass
Can migratory robins ‘see’ Earth’s magnetic field at night?
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NewsRace to understand Sars-CoV-2 variants amid fears virus might evade vaccines
Biochemical basis behind coronavirus variants’ success could hold key to defeating them
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BusinessBMS and Eisai agree antibody-drug conjugate commercialisation deal
Companies will jointly develop cancer treatment, with BMS paying up to $3 billion for shared rights
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ResearchSortase A strategy could see ribosomal products reach further across chemical space
Compound libraries set to benefit from process that harnesses promiscuity of post-translation enzymes
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BusinessRegeneron’s Covid-19 antibodies help those who can’t make their own
Regn-Cov2 reduces deaths and shortens hospitalisation for these patients, even when given at late stages of infection
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ResearchBlocking bacteria’s self-poisoning mechanism weakens their antibiotic resistance
Stopping bacteria from producing hydrogen sulfide in response to drugs could help overcome antimicrobial resistance
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BusinessAlzheimer’s antibody gets surprise US approval
Good news for industry and future drug approvals, but physicians doubt it will be effective for most patients