Biotechnology and bioengineering – Page 2
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NewsAll clinical research using germline genome editing banned in China
New guidelines follow creation of first gene-edited babies three years ago by He Jiankui
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FeatureIs DNA the future of digital data storage?
DNA is being explored as a long-term solution to preserving digital information for future generations. Nina Notman reports
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ResearchNew gene-editing tool found in bacterium could carry out extensive genome remodelling
Highly selective mechanism can insert, remove and flip large portions of DNA
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ResearchGenetic engineering feat coaxes yeast to produce valuable vaccine compound
Yeast could head off supply fears for vaccines ingredient by replacing soapbark tree as source of adjuvant
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BusinessPan-cancer approval shows huge potential for antibody–drug conjugates
Enhertu gains approval based on gene expression rather than tumour location
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ResearchMicrobial enzymes cut a path towards universal blood for transfusions
Slicing off glycans revealed new, previously unknown antigens that must be removed to produce O-type blood
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ResearchSelf-dyeing vegan leather made by genetically engineered bacteria
Material can be shaped into shoes and wallets, offering a sustainable alternative to traditional leather
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BusinessUS government moves to block Chinese biotechs’ operations
WuXi Apptec and others accused of national security risk, as trade groups back legislation limiting their activities
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FeatureSmall molecules that switch up cell development could transform medicine
Turning mature somatic cells back into flexible stem cells using small molecules could revolutionise medicine, especially for regeneration and cancer. Philip Ball reports
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ResearchE. coli rewired to shift carbon flow towards C4 chemicals
Bioengineering strategy creates evolutionary advantage linking cell growth with product formation
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ResearchAutonomous platform engineers enhanced proteins
AI-powered robotic system designs and optimises proteins following its own ‘scientific method’
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BusinessPharmaceuticals roundup 2023
Regulatory and pricing reforms have topped industry agendas in 2023, while weight loss drugs surged and Covid-19 therapies waned
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BusinessDanaher completes $5.7 billion Abcam acquisition
Deal proceeded despite significant opposition from founder and ex-chief Jonathan Milner
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ResearchBiocatalysis breakthrough enables synthesis of lactam building blocks for drugs
Enzymatic cyclisation of oxazolone reagents offers a cheap and simple route to important antibiotic precursor
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ResearchDNA-damaging device could make mutant discovery safer and simpler
Cool microplasma jets create a stream of radicals that induce mutations
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BusinessUK becomes first country in the world to authorise a Crispr-based gene therapy
Treatment aims to cure patients with β-thalassaemia and sickle-cell disease
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ResearchSynthetic yeast genome project creates strain with over 50% synthetic DNA
Entirely artificial organism opens up door to designer yeast with biotechnology applications
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ResearchControlling insulin activity in cells with ‘DNA origami’
Insulin–DNA nanorods elicit geometry-dependent insulin activity, which could lead to more targeted treatments for diabetes
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ResearchGenetic-editing of chickens protects them from catching the flu
Approach heralds new way to make animals resistant to disease
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Research’This is just the beginning’: RNA editing set to democratise viral engineering
Crispr-based system could ease development of novel RNA therapies