Biotechnology and bioengineering – Page 5
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OpinionAlzheimer’s, amyloid and abandoned antibodies
Biogen’s aducanumab is stumbling into obscurity. Where does that leave the amyloid hypothesis?
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ResearchEncapsulated bacteria show promise as injectable living drugs factories to treat diseases
Engineered E. coli produce insulin and vaccines in vivo
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ResearchLight-activated cancer treatment uses tumour-targeting enzymes to cut side effects
Enzymatic activation of a photosensitive prodrug in cancerous cells shows promise in mice
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ResearchBreaking bacteria’s genetic silence to synthesise antibiotics that evade resistance
Prospecting in bacterial genomes offers hope in search for new antimicrobial drugs
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ResearchGene therapy showcases technique to extend life in mice
Lab mice lived significantly longer after receiving one of two genes, delivered using a mouse herpes virus
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BusinessWhat is the future of Covid-19 pharmaceuticals?
Firms anticipate long-term markets for prevention and treatment
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ResearchCancer progression and harmful bacteria tracked with next-generation sequencing
Proof-of-principle study keeps an eye on leukaemia mutations and bacterial strains in patients
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FeatureThe incredible antibodies of sharks, llamas and camels
Sharks and llamas share a strange quirk of their immune systems. Hayley Bennett finds out how their ‘nanobodies’ could help us tackle Covid and a host of other diseases
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ResearchAI-engineered enzyme eats entire plastic containers
Enzyme with only five amino acid alterations depolymerises 51 different PET products faster and at lower temperature than other proteins
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ResearchYeast engineered to convert methanol into heparin
Production levels are currently low, but researchers hope the method could one day mean pharma doesn’t have to rely on animals for this essential medicine
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ArticleNanotechnology for a healthier, cleaner world for all
Using novel polymer fluorophores to study, detect and treat life-threatening diseases
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BusinessPatent office cements priority for Crispr gene editing in cells
Nobel laureates’ failed challenge means companies may need extra patent licenses
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BusinessModerna sued over Covid-19 vaccine-related patents
Arbutus and Genevant say lipid nanoparticles that protect mRNA infringe six key patents
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ResearchReprogrammed bacterium turns carbon dioxide into chemicals on industrial scale
Process achieved at industrial scale in 120 litre reactor
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FeatureSequencing one cell at a time
New advances that allow scientists to uncover the molecular differences between individual cells could revolutionise medicine, Ian le Guillou finds
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ResearchEngineered enzyme speeds up sedate organic reaction
Biochemical optimisation applied to the Morita–Hillman–Baylis reaction
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FeatureThe labs pointing to a greener future for Africa
Tackling climate is not just a job for scientists in more developed countries. Munyaradzi Makoni talks to researchers in Kenya and South Africa to find out more
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ResearchProkaryotes programmed to produce paracetamol avoid pervasive petrochemicals
Genetically modified E. coli serve as green factories for painkillers
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FeatureThe science of breast milk and baby formula
Nina Notman reveals how breast milk research is inspiring a new generation of infant formulas and opening the door to therapeutic advances
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ResearchIndividual proteins identified with world’s tiniest ruler
Nanosized caliper that can identify individual proteins could ‘do for proteins what next-generation sequencing did for DNA’