All articles by Derek Lowe – Page 2
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OpinionNavigating the literature torrent
It’s humanly impossible to filter and read everything worthwhile – let’s embrace assistance
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OpinionBringing drug manufacturing back home
Pharmaceutical supply chains are international, complex and opaque. Is there a better way?
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OpinionRegulators must follow their heads, not their hearts
The 2019 US approval of antibiotic Recarbrio seems not to have met the normally expected standards
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OpinionWill a court overturn abortion drug’s approval?
Tangle between regulation and politics makes uncomfortable viewing from industry
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OpinionMeeting the tigers of the lab
Practical teaching strikes a balance between removing hazards and learning to respect them
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OpinionTurning negative results into positives
Publishing unsuccessful experiments is more important than ever as we try to train machines in chemistry
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OpinionThe psychology of our future with AI
It’s time to accept that digitalisation is changing laboratory work, and embrace the opportunity
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OpinionSetting drug development speed records
The pandemic treatment sprint was spectacular, but hard to match under less unusual circumstances
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OpinionEmbracing oddities
When new chemistry looks like alchemy or witchcraft, it’s worth taking notice
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OpinionNobel vision
Looking beyond the here-and-now let click chemistry open up a whole new world of possibility
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OpinionDo science courses need hands-on labs to be effective?
The practical lab is where abstract theory connects to physical reality
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OpinionWhy AlphaFold won’t revolutionise drug discovery
Protein structure prediction is a hard problem, but even harder ones remain
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OpinionMay cause side effects
The dose makes the poison, but understanding unwanted drug interactions is complicated
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OpinionAlzheimer’s, amyloid and abandoned antibodies
Biogen’s aducanumab is stumbling into obscurity. Where does that leave the amyloid hypothesis?
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OpinionCatalogues of complexity
The tangled web of fine chemicals supply frequently throws up surprises
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OpinionExit strategy
Overcoming a major setback showed Derek Lowe could make it through graduate school
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OpinionA spanner in the works
Most drugs work by breaking or stopping something, rather than by making something faster or better
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OpinionScents and sentimentality
Deprived of familiar lab odours, Derek Lowe indulges in some nasal nostalgia
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OpinionThe shadow of drug resistance
Why do some medicines stop working, and can we avoid it for Covid-19 antivirals?
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OpinionThe law of conservation of data
AI and machine learning are useful and powerful, but they need high quality data inputs that aren’t available yet for drug discovery