All articles by Derek Lowe – Page 2
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OpinionMeeting the tigers of the lab
Practical teaching strikes a balance between removing hazards and learning to respect them
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OpinionTurning negative results into positives
Publishing unsuccessful experiments is more important than ever as we try to train machines in chemistry
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OpinionThe psychology of our future with AI
It’s time to accept that digitalisation is changing laboratory work, and embrace the opportunity
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OpinionSetting drug development speed records
The pandemic treatment sprint was spectacular, but hard to match under less unusual circumstances
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OpinionEmbracing oddities
When new chemistry looks like alchemy or witchcraft, it’s worth taking notice
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OpinionNobel vision
Looking beyond the here-and-now let click chemistry open up a whole new world of possibility
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OpinionDo science courses need hands-on labs to be effective?
The practical lab is where abstract theory connects to physical reality
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OpinionWhy AlphaFold won’t revolutionise drug discovery
Protein structure prediction is a hard problem, but even harder ones remain
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OpinionMay cause side effects
The dose makes the poison, but understanding unwanted drug interactions is complicated
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OpinionAlzheimer’s, amyloid and abandoned antibodies
Biogen’s aducanumab is stumbling into obscurity. Where does that leave the amyloid hypothesis?
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OpinionCatalogues of complexity
The tangled web of fine chemicals supply frequently throws up surprises
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OpinionExit strategy
Overcoming a major setback showed Derek Lowe could make it through graduate school
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OpinionA spanner in the works
Most drugs work by breaking or stopping something, rather than by making something faster or better
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OpinionScents and sentimentality
Deprived of familiar lab odours, Derek Lowe indulges in some nasal nostalgia
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OpinionThe shadow of drug resistance
Why do some medicines stop working, and can we avoid it for Covid-19 antivirals?
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OpinionThe law of conservation of data
AI and machine learning are useful and powerful, but they need high quality data inputs that aren’t available yet for drug discovery
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OpinionReverse combustion is preparing for takeoff
Where burning hydrocarbons is unavoidable, creating them from atmospheric carbon is a promising option
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OpinionAll work and no play
Is the long-hours culture of academic organic chemistry laboratories finally changing?
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OpinionWhere are the Covid-19 drugs?
Small molecules appear to be lagging behind development of vaccine and antibody treatments
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OpinionThe price of failure
Drug market structures and high R&D failure rates can tempt companies into bad pricing behaviour