All articles by Derek Lowe – Page 4
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OpinionWill computers ever discover drugs from scratch?
With enough understanding and computing power, it should be possible, but will it happen?
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OpinionEmbracing structural disorder
Medicinal chemists need to overcome their fear of fuzzy proteins
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OpinionHas x-ray had its day?
Will the giant of structure determination be toppled by blasts from electron beams?
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OpinionThe silent rise of the robots
Mechanical helpers have been creeping into our labs for decades
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OpinionIs this a golden age of new drug classes?
A host of new treatment modes are hitting the clinic and the market
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OpinionIt's complicated
In a complex world, binary answers are often requested but rarely sufficient
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Opinion
Management by numbers
Reducing intellectual processes to metrics runs the risk of people working to the numbers not the goal
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OpinionWould you buy synthetic wine?
Can we replicate the chemical profiles of famously expensive drinks? And would people drink them?
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OpinionWe’re going to need a bigger flask
Scaling up reactions is easy to get wrong in a variety of ways
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OpinionWhat are the rate-limiting steps in drug discovery?
Getting more drugs to market is not just a chemistry problem
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OpinionHow science shapes our psychology
We learn to embrace the unexpected, follow evidence over opinion and accept that most experiments fail
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OpinionWhat would a 1980s student make of modern research?
Nano- and macromolecular science might make for a shocking read in the launderette
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OpinionThe projects drug companies wish they’d never started
Failures are common in drug research, but some are bigger than others
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OpinionFeeding the confusion
When it comes to working out what foods do to our bodies, mostly we just don’t know
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Opinion'If I'd discovered metformin, I'd have tossed it aside...'
Trusting our intuition too strongly highlights how little we know about chemical activity
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OpinionThe three muses of scientific discovery
Inspiration, experimentation and happy accidents are all pathways to a breakthrough
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OpinionWhy combination pills aren’t always the answer
The challenges of medicines containing multiple drugs aren’t going away