All articles by Derek Lowe – Page 6
-
OpinionDon’t fear the Crispr
Does simple gene-editing mean the end of traditional medicinal chemistry? Probably not
-
-
OpinionNow you’re talking my language
Chemistry would be impossible without a hidden fluency that many of us don’t even realise we have, says Derek Lowe
-
OpinionLet's see that again
Has chemistry evaded the reproducibility crises affecting other branches of science? Or is it just a question of scale, asks Derek Lowe
-
-
OpinionThrowing things over the fence
Saying ‘That’s someone else’s problem’ is asking for trouble, says Derek Lowe
-
OpinionDrugs don’t grow on trees
The trope of companies profiteering from academic discoveries doesn’t bear much scrutiny, says Derek Lowe
-
OpinionPride comes before a fall
In labs it’s important not to let familiarity breed complacency, says Derek Lowe
-
-
OpinionEmerging from Babel
Will English ever lose its place as the lingua franca of chemistry, asks Derek Lowe
-
OpinionWhat the market will bear?
Martin Shkreli’s monopolising model poses some uncomfortable questions for the pharma industry, says Derek Lowe
-
OpinionSpice up your compounds
An occasional foray into uncharted territory is the hot sauce of medicinal chemistry, says Derek Lowe
-
OpinionA risky business
Graduate research is likely the most risky time of a chemist’s career, says Derek Lowe
-
OpinionA precision instrument?
Chemists and biologists have different expectations when it comes to data, says Derek Lowe
-
OpinionMissing the target
There are plenty of things that small molecule drugs can’t touch, says Derek Lowe, and it’s not for want of trying
-
OpinionMagic molecule modifiers
Late stage functionalisation can seem supernaturally powerful, says Derek Lowe – if you’ve got the nerve to try it
-
OpinionMissing mathematics?
While you may not need differential calculus every day, mathematics is the basis of scientific thinking, says Derek Lowe
-
OpinionAnalogues by catalogue
Buying in screening compounds directly feels like cutting out the synthetic chemist middleman, says Derek Lowe
-
OpinionTantalising technology
Computer-assisted drug design always looks like it’s just about to work, says Derek Lowe, but the reality is complicated
-
OpinionThe smell of success
Laboratory aromas conjure memories and emotions from elation to a sudden need to vomit, says Derek Lowe