All articles by Derek Lowe – Page 7
-
OpinionMissing mathematics?
While you may not need differential calculus every day, mathematics is the basis of scientific thinking, says Derek Lowe
-
OpinionAnalogues by catalogue
Buying in screening compounds directly feels like cutting out the synthetic chemist middleman, says Derek Lowe
-
OpinionTantalising technology
Computer-assisted drug design always looks like it’s just about to work, says Derek Lowe, but the reality is complicated
-
OpinionThe smell of success
Laboratory aromas conjure memories and emotions from elation to a sudden need to vomit, says Derek Lowe
-
OpinionIgnorance is no defence
In a chemistry lab, what you don’t know really can hurt you, says Derek Lowe
-
OpinionProgress at the pace of the slowest
Chemistry is rarely the rate-limiting process in getting a drug to market, says Derek Lowe
-
OpinionChemical space is big. Really big
You think it’s a long way to the back of your screening libraries? That’s peanuts to chemical space, says Derek Lowe
-
OpinionGarbage in, garbage out
The rise of low-quality and predatory open access journals and conferences worries Derek Lowe
-
OpinionDeath of a reagent
Fashion and progress combine to mean some reactions and reagents persist, while others fall by the wayside, says Derek Lowe
-
OpinionThe crystal ball that can tell lies
X-ray structures are not necessarily definitive, says Derek Lowe, especially when it comes to biomolecules
-
OpinionToo big to innovate?
How strong is the correlation between company size and research productivity, asks Derek Lowe
-
OpinionMessy megamergers
Big company buyouts are more about immediate gains and rarely consider the impact on research, says Derek Lowe
-
OpinionEngineering serendipity
It takes more than random stumbling to find new reactions, says Derek Lowe
-
OpinionKnown unknowns
New molecules with unpredictable biological activity deserve sensible amounts of respect, says Derek Lowe
-
OpinionTools of the trade
Derek Lowe wonders what the most life-changing instrument for organic chemists is, and what might be missing from the toolbox
-
OpinionBeelzebub Pharma Ltd
Derek Lowe thinks the Devil’s R&D management schemes might be scarily familiar
-
OpinionIs there a drug for that?
Derek Lowe ponders whether anything is truly ‘undruggable’ if we look in the right places
-
OpinionRolling boulders uphill
Is Derek Lowe troubled by his failure to develop a compound that has made it to the pharmacy shelf?
-
OpinionNatural born chemists
Redesigning nature’s catalysts is tantalising but tricky, says Derek Lowe
-
OpinionWhat's the use?
Not every reaction can be run in a bucket, says Derek Lowe, but there are limits to what should be classed as ‘useful’