All directed evolution articles
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ResearchTeaching enzymes new reactions through genetic code expansion and directed evolution
Anthony Green’s research group at the University of Manchester, UK, reengineers enzymes to have catalytic functions beyond those found in nature
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ResearchEngineered enzymes break down silicon–carbon bonds in siloxane, an emerging pollutant
Directed evolution offers a way to tackle waste silicone
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ResearchAutonomous platform engineers enhanced proteins
AI-powered robotic system designs and optimises proteins following its own ‘scientific method’
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ResearchArtificially expanded genetic alphabet evolves enzymes for the first time
Libraries of short DNA sequences incorporating synthetic nucleotides perform better as enzymes than ordinary DNA
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ResearchDiverse pharmaceutical building blocks prepared with evolved enzymes
Computation guides enzyme evolution to produce high-value drug compounds
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ResearchNMR spectroscopy used to guide evolution of better enzymes
Identifying mutagenic ‘hotspots’ could speed development of new proteins
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ResearchArtificially evolved enzyme tackles tricky cross coupling
Directed evolution on the metalloenzyme cytochrome P450 creates a catalyst for making macrocyclic antibiotics
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ResearchEngineered enzyme speeds up sedate organic reaction
Biochemical optimisation applied to the Morita–Hillman–Baylis reaction
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ResearchEvolved enzymes carry out new-to-nature radical chemistry
Directed evolution produces enzymes that can ‘tame’ radical intermediates for asymmetric catalytic reactions
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FeatureArtificial enzymes: catalysis by design
Enzymes are nature’s ultimate catalysts and chemists are now on the verge of making their own versions from scratch
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ResearchResurrected enzyme aces cellulose catalysis
Protein that survived extreme conditions on early Earth could be a boon for biofuel industry
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ResearchEnzyme evolved to selectively functionalise carbon–hydrogen bonds
Lactam libraries created by engineered bacterial enzyme offer new way to fight antibiotic resistance
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ResearchEnzyme redesign magnifies rare sugar synthesis
Tweaks could allow scientists to explore the commercial potential of an unusual disaccharide found in Japanese sake
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NewsIupac names 10 chemistry innovations that will change the world
Nanopesticides, MOFs and 3D bioprinting among potential breakthrough technologies for a sustainable future
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ResearchEnzyme evolved that can perform reactions new to nature
New possibilities for organic synthesis with enzymatic C–H functionalisation
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ResearchEnzyme ancestors resurrected to boost thermal stability
Scientists constructing enzyme library make serendipitous discovery