Drug discovery and development – Page 12
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FeatureEngineering a handshake for proteins
Once considered undruggable, chemists are beginning to grasp protein–protein interactions, according to Ian Le Guillou
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NewsFirst Covid-19 challenge study working with live virus planned for the UK
Pending ethics panel approval, healthy volunteers would be infected with Sars-CoV-2 to help understand disease and test vaccines
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PodcastSofosbuvir
The hepatitis C drug that made waves when first launched – quicker to work and with fewer side effects than existing drugs, but it came with a hefty price tag
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PodcastBedaquiline
The first TB drug approved in 40 years gave hope to sufferers of drug resistant tuberculosis and ushered in a new class of antibiotics
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OpinionBlood offering
Antibodies in various forms could bridge the Covid-19 treatment gap until a vaccine is available
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OpinionJumping the vaccine queue
Deals between companies and rich governments offset manufacturing risks, but must not compromise supplies to those in need
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BusinessCovid-19 vaccine deals risk skewing supply
International accords including Covax aiming to ensure equitable distribution to poorer countries
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WebinarDeveloping small-molecule degraders using chemoproteomics
Discover how chemoproteomics can inform the development of small molecule degraders
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BusinessProtein-based Covid-19 vaccines could overshadow rivals
Although slower to develop, protein-based vaccines are well understood with a strong record of safety and effectiveness
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ResearchDNA-compatible C–H activation method set to benefit drug discovery
Larger and more diverse DNA-encoded libraries on the cards thanks to new tool
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NewsRush to approve Covid vaccine prompted by politics may end in disaster
Push by governments to pass a vaccine without appropriate evidence could damage fight against virus
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BusinessRussian Covid-19 vaccine data raises questions
Suspected data manipulation or fabrication casts shadows over safety trial report for hastily-approved Sputnik V
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OpinionFacing the challenge of vaccine trials
Russia’s Covid-19 gamble is a stark contrast to even accelerated clinical programmes
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BusinessRussian vaccine launch shocks scientists
Sputnik V to be approved without large human trial data
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BusinessEncouraging signs from initial Covid-19 vaccine trials
Human trials deliver positive immune responses, while primate challenge studies suggest protection is possible
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FeatureWhy is cystic fibrosis so hard to treat?
Claire Jarvis talks to the scientists trying to find new drugs to treat the inherited lung condition
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ResearchTranslating snail venom research from beach to bench and beyond
Meet Mandë Holford, an interdisciplinary scientist following tangents that arise when exploring the molecular-level workings of venom peptides
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WebinarIlluminating research with the LightOx PhotoReact 365 benchtop photoreactor
Learn about the LightOx PhotoReact – a benchtop photoreactor enabling reproducible irradiation for photochemical and photobiological applications
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OpinionLooking beyond the next wave
We need to apply lessons from Covid-19 to tackle antimicrobial resistance and climate change