Drug discovery and development – Page 15
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PodcastMinoxidil and Finasteride
Catherine Hodges explores the chemical solutions to thinning hair and patchy beards, examining the popularity of minoxidil and the cautionary tale of finasteride
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BusinessRNA vaccines are coronavirus frontrunners
Several groups have potential Sars-CoV-2 vaccines ready or close to testing, thanks to rapid development pathways
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ResearchCheating bacterium becomes antibiotic-tolerant at expense of other species
Coexistence triggers counterintuitive antibiotics response in bacteria, which could be used to tackle hardy species
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ResearchMetal complexes outperform organics in antimicrobial analysis on crowdsourced compounds
Could this study prompt drug developers to rethink their reluctance to making metal-based pharmaceuticals?
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ResearchAI tool screens 107 million molecules, discovers potent new antibiotics
Deep learning approach could help in fight against drug-resistant bacteria
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ResearchDetailed 3D coronavirus spike map offers hope for vaccine development
Structure determined at ‘remarkable’ speed in little over a month
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OpinionTwo heads are better than one
Bifunctionals show that sometimes simply tethering two useful molecules together unlocks some useful activity
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FeatureAdjuvants: vaccines’ hidden helpers
Anthony King examines a crucial part of vaccines that can significantly boost their performance, but which often go unrecognised
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BusinessThe race to fight coronavirus
While genome sequences enable testing and vaccine efforts, companies are donating existing antiviral drugs to explore repurposing
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ArticleTransforming innovation for startups
Green polymer specialists Novomer and biotech startup SynbiCite optimised industrial and biotech processes using design of experiment software from JMP
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FeatureThe search for cancer vaccines
Claire Jarvis looks at ongoing work to prevent the disease – and convince a sceptical community of their seriousness
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BusinessCancer and rare diseases dominated 2019 drug approvals
More streamlined review processes and changing R&D priorities have contributed to sustained increase in new medicines
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OpinionStartup EQRx claims it can revolutionise drug discovery
If it can deliver reasonable drugs at knock-down prices, will providers be convinced?
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ResearchSugars designed to disrupt bacterial cell wall biosynthesis
Rare monosaccharides explore concept for new narrow-spectrum antibiotics
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WebinarRenewable resources: the future role of lignins
Learn how to gain more detailed insight into your lignin samples with Antje Potthast from Waters
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ResearchSynthetic strategy exploits fluxional nitrogen to deliver three chiral centres for the price of one
Innovative method amplifies chirality and complexity in medicinally relevant cyclic hydrazines
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BusinessRevived Alzheimer’s antibody met with guarded optimism
Biogen’s aducanumab offers the possibility to slow disease progress, but regulators will likely want more convincing evidence
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ResearchInorganic fragment library ready to help drug discoverers reach neglected regions of chemical space
A new approach to fragment-based drug design
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NewsPoor antibiotic stewardship blamed as India found to be superbug’s birthplace
Spread of superbugs a growing problem for the subcontinent
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ResearchTotal synthesis of H. pylori antigen creates starting point for gastric cancer vaccine
Remote participation strategy helps chemists make sterically-congested repeating fragment