Drug discovery and development – Page 19
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FeatureCan we live forever?
We are now living longer than ever before, but not always in perfect health. Anthony King talks to the researchers working to extend our healthspan
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ResearchAlzheimer’s linked to infection of the brain by gum disease bacterium
Drug firm is developing treatment to inhibit bacterial enzymes believed to be damaging important protein
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ResearchScreening strategy pursues photocatalytic couplings for drug discovery
High-throughput screening and flow-based scale-up combo identifies chemistry needed to functionalise drug fragments and obtain useful amounts of product
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OpinionWhat are the rate-limiting steps in drug discovery?
Getting more drugs to market is not just a chemistry problem
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ResearchCrowdsourced drug discovery pits half-forgotten compounds against neglected diseases
45 research groups donate 350 compounds to the first crowdsourced screening library
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ResearchNanodecoys lure and trap Zika virus
Gelatin nanoparticles camouflaged by mosquito membrane mop up virus and stop it crossing placenta
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ResearchErythropoietin benefits from controlled sugar-coating
Click chemistry allows glycosylation at virtually any synthetic stage
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NewsX-ray crystallographer to oversee Rosalind Franklin Institute
Structural biologist James Naismith to become first director of UK’s new national life sciences institute
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BusinessBreaking the silence of RNA interference drugs
A wave of treatments is set to follow the first approval of an RNAi therapy
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ResearchFirst oral antibiotic booster for four decades could tackle drug resistance
Sulfate-masking strategy makes bacterial enzyme inhibitor an easy pill to swallow
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OpinionPassing through checkpoints
A new breed of cancer treatments highlights what’s possible when industry concentrates its efforts
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ResearchNew peptide destroys Zika virus in brain for first time
Engineered molecule ruptures virus particles to tackle infection
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OpinionThe potential of promiscuity
Nobel recognition for a concept whose benefit to humankind is far from being truly realised
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BusinessCancer immunotherapy spreads rapidly
New approvals and expanded use for checkpoint inhibitor drugs illustrate the power of Nobel-winning science
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FeatureHow chemical evolution took the 2018 chemistry Nobel prize
Emma Stoye has the full story of how Frances Arnold, George Smith and Greg Winter put evolution to work in the lab
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OpinionThe projects drug companies wish they’d never started
Failures are common in drug research, but some are bigger than others
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ResearchNanoparticles offer extensive new cure for snakebites
Treatment neutralises venom, reducing tissue damage
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BusinessCleaning up clinical trials
Campaigns to enforce complete and correct reporting of trial data are beginning to take hold
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NewsWhat is directed evolution and why did it win the chemistry Nobel prize?
If you’ve got questions about yesterday’s chemistry Nobel prize then we’ve got answers