Drug discovery and development – Page 20
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NewsWhat is 'checkpoint therapy' and why did it win the medicine Nobel prize?
James Allison and Tasuku Honjo released the ‘brakes’ on our immune system to combat cancer
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NewsImmune-stimulating cancer treatment takes 2018 medicine Nobel
James Allison and Tasuku Honjo receive science’s highest honour for discovering how cancer stops immune cells from attacking
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BusinessLandmark China cancer drug full approval ‘first of a wave’
Chi-Med’s fruquintinib is a result of China’s evolving drug innovation and regulation
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ResearchHepatitis C drug lead designed to target virus RNA
Gene-to-RNA-to-medicine pipeline possible thanks to technique that reveals interactions between RNA and small molecules
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NewsBitter feuding at Cochrane healthcare audit body paralyses organisation
One member has been expelled from the governing board while another four resign with accusations of pharmaceutical industry bias flying
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ResearchGenentech antibiotic quells resistance
Modified arylomycin combines high potency with new mechanism of action
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OpinionFeeding the confusion
When it comes to working out what foods do to our bodies, mostly we just don’t know
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FeatureThe quest to cure HIV
Although HIV–Aids can now be managed quite well with antiretroviral drugs, there is still no cure. Anthony King talks to the scientists trying to find one
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BusinessUS approves first RNA interference drug
Alnylam’s Onpattro (patisiran) can treat a rare hereditary disease by silencing a specific gene
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ResearchBismuth drugs kill bacteria by disrupting metabolism
Scientists throw kitchen sink of omics techniques at understanding complicated response of prevalent human pathogen to bismuth drug
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FeatureFrom folklore to pharmacy
Although many drugs have in the past come from plants, Hayley Bennett discovers that it’s hard work getting them approved today
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BusinessVaccine scandal and heart drug recall show China’s pharma struggles
Fifteen arrests amid evidence of bribery related to vaccines, despite new standards and penalties for fraud
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BusinessNovartis exit from antibiotics a setback for race against resistance
Experts say business models must change to halt big pharma exodus
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ResearchArtificial intelligence seeks out new anticancer drugs
A combination of machine learning methods yields promising results for drug discovery
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Opinion'If I'd discovered metformin, I'd have tossed it aside...'
Trusting our intuition too strongly highlights how little we know about chemical activity
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NewsWHO gears up to solve the world’s antivenom crisis
Clinical trials planned to take on scourge of substandard, untested medicines
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ResearchFour step route to carbotricycles
Elegant strategy that directly assembles 5–8–5 scaffolds from simple precursors paves way to a new library of bioactive compounds
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ResearchTool to navigate chemical space aims to be ‘Google Maps of drugs’
Software allows links between 8000 drugs and 47,000 compounds of environmental concern to be explored in 3D
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NewsNew life sciences institute wants to make drug discovery 10 times more efficient
The UK’s £103 million Rosalind Franklin Institute will unite robotics, chemistry and biophysics to generate drug candidates within weeks