Drug discovery and development – Page 21
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NewsVaccines central to efforts to head off latest Ebola outbreak
Ring vaccination strategy could halt disease in its tracks provided health systems can cope
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OpinionThe three muses of scientific discovery
Inspiration, experimentation and happy accidents are all pathways to a breakthrough
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NewsWhy antibiotic pollution is a global threat
Rising antibiotic resistance caused by pollutants needs action
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ArticleAre polymer medicines viable therapeutics?
Combining small-molecule medicines with polymers could offer big rewards for pharmaceutical researchers
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ArticleThe dark side of chemical patents
Unloved, ignored and misunderstood but could all that change?
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FeatureUnderstanding Alzheimer’s
After hundreds of failed drug candidates, James Mitchell Crow asks if this is the last roll of the dice for the amyloid theory of Alzheimer’s disease
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OpinionWhy combination pills aren’t always the answer
The challenges of medicines containing multiple drugs aren’t going away
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BusinessNovartis’ $8.7bn AveXis deal shows gene therapy appeal
Acquisition indicates the value of potentially permanent cures for inherited diseases
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NewsGetting a better grasp of manganese to fight flu
A drug that can hold onto two metals atoms rather than just one becomes 1000 times more potent at knocking out a flu virus enzyme
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BusinessFit for repurpose
Drugs that can be used for new indications offer a potentially cheaper pathway – but only if the investors can recoup their costs
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ResearchBacteria churn out a million potential protein drugs
Modified bacteria produce enormous library of macrocycles, one of which inhibits a HIV protein
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FeatureCuba: socialism, cigars and biotech
Nina Notman learns how biotechnology could potentially overtake cigars as Cuba’s most famous export
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ArticleFive innovative technologies for health
How do healthcare products get from academic or start-up labs to the clinic? With a little help from places like the Centre for Process Innovation
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ArticleDriving pharmaceutical innovation
Making drugs is neither easy nor cheap – but catalysts, flow chemistry and a knowledge of intermolecular interactions can help
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ArticleDissolving insoluble drugs
How spray drying can help with solubility and bioavailability challenges in drug development
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ArticlePlatinum metal complexes in medicine
The history of cisplatin, the drug that is still the gold – or should that be platinum? – standard in cancer drugs
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ArticleBiosensors, wearables and virtual biotech
In a world that is racing ahead with new technologies, has the drug development process distanced itself from the patients it ultimately provides for?
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ArticleWhy biocatalysis is so on trend
Biocatalysis has come a long way from just beer – there’s an enzyme for nearly everything
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ArticleThe ever-increasing attraction of biologics
Biologics promise targeted treatments for a range of conditions – if we can overcome the technological challenges
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FeatureThe antibiotic countdown
Where are the next generation of antibiotics going to come from? Clare Sansom looks at the pipeline