Drug discovery and development – Page 23
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BusinessVaccine scandal and heart drug recall show China’s pharma struggles
Fifteen arrests amid evidence of bribery related to vaccines, despite new standards and penalties for fraud
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BusinessNovartis exit from antibiotics a setback for race against resistance
Experts say business models must change to halt big pharma exodus
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ResearchArtificial intelligence seeks out new anticancer drugs
A combination of machine learning methods yields promising results for drug discovery
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Opinion'If I'd discovered metformin, I'd have tossed it aside...'
Trusting our intuition too strongly highlights how little we know about chemical activity
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NewsWHO gears up to solve the world’s antivenom crisis
Clinical trials planned to take on scourge of substandard, untested medicines
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ResearchFour step route to carbotricycles
Elegant strategy that directly assembles 5–8–5 scaffolds from simple precursors paves way to a new library of bioactive compounds
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ResearchTool to navigate chemical space aims to be ‘Google Maps of drugs’
Software allows links between 8000 drugs and 47,000 compounds of environmental concern to be explored in 3D
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NewsNew life sciences institute wants to make drug discovery 10 times more efficient
The UK’s £103 million Rosalind Franklin Institute will unite robotics, chemistry and biophysics to generate drug candidates within weeks
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NewsVaccines central to efforts to head off latest Ebola outbreak
Ring vaccination strategy could halt disease in its tracks provided health systems can cope
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OpinionThe three muses of scientific discovery
Inspiration, experimentation and happy accidents are all pathways to a breakthrough
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NewsWhy antibiotic pollution is a global threat
Rising antibiotic resistance caused by pollutants needs action
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ArticleAre polymer medicines viable therapeutics?
Combining small-molecule medicines with polymers could offer big rewards for pharmaceutical researchers
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ArticleThe dark side of chemical patents
Unloved, ignored and misunderstood but could all that change?
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FeatureUnderstanding Alzheimer’s
After hundreds of failed drug candidates, James Mitchell Crow asks if this is the last roll of the dice for the amyloid theory of Alzheimer’s disease
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OpinionWhy combination pills aren’t always the answer
The challenges of medicines containing multiple drugs aren’t going away
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BusinessNovartis’ $8.7bn AveXis deal shows gene therapy appeal
Acquisition indicates the value of potentially permanent cures for inherited diseases
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NewsGetting a better grasp of manganese to fight flu
A drug that can hold onto two metals atoms rather than just one becomes 1000 times more potent at knocking out a flu virus enzyme
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BusinessFit for repurpose
Drugs that can be used for new indications offer a potentially cheaper pathway – but only if the investors can recoup their costs
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ResearchBacteria churn out a million potential protein drugs
Modified bacteria produce enormous library of macrocycles, one of which inhibits a HIV protein