Drug discovery and development – Page 24
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ArticleSygnature Discovery
Sygnature Discovery is part of an innovative partnership to bolster the life science sector in Nottingham
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OpinionUnpicking a clinical trial death
A new study shows up off-target effects of a drug that proved deadly, and highlights the pitfalls of drug discovery
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FeatureAccess to drugs: a failure of pharma?
Many people around the world are either unable to afford the drugs they need, or their conditions have not been addressed by pharma R&D. Sarah Houlton investigates
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ResearchModified antibiotic beats superbug resistance
Adding functional groups to vancomycin gives it extra modes of attack against resistant bacteria
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OpinionDrug pricing must be more transparent
Pricing is a complex issue - how can we make it clearer?
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BusinessPollution from Indian drugmakers drives drug resistance
Areas around manufacturing sites still heavily contaminated with antimicrobials and breeding multidrug-resistant pathogens
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ResearchHow total synthesis is creating antibiotics
Macrolide synthesis could reinvigorate the antibiotic pipeline
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FeatureCovalent inhibitor drugs
Exceptions to a long-held rule against chemically bonding to biological targets are powering new cancer medicines, finds Andy Extance
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ResearchMaple syrup enhances antibiotics
A phenol-rich mixture extracted from maple syrup allows much smaller doses of antibacterial drugs to achieve the same results
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NewsHow we are fighting tropical diseases
Repellents and vaccines are useful but still need further improvement
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BusinessExpanding precision medicine beyond cancer
Exclusive interview with Koustubh Ranade, vice president of R&D at MedImmune
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ResearchPutting the ‘ant’ in antibiotics
Antibacterial polyketides uncovered in the most unusual of places
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NewsEuropean science groups voice concern over recent US policies
Leaders in Europe are being warned about the potential impacts of President Trump’s policies on research and innovation
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News€1 million prize awarded for quick test to cut antibiotic use
Diagnostic device could help fight antimicrobial resistance by determining whether or not an infection is caused by bacteria
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ResearchMolecular structure is teixobactin’s pièce de résistance
Study builds scientists’ arsenal against drug-resistant superbugs
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NewsAlzheimer’s disease: have drug developers been on the wrong track?
Dementia drug developers urged to look beyond amyloid
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NewsVaccine coalition to target emerging infectious diseases
Fund attempting to raise $1 billion to develop vaccines before an epidemic strikes
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BusinessTaming vaccines with chemistry
Vaxxilon aims to simplify vaccine development by replacing biological components with well-defined synthetic molecules
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FeatureNew opioid drugs
Creating powerful new painkillers is a constant battle against side-effects – particularly addictions. James Mitchell Crow reports