Drug discovery and development – Page 29
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News
US spends billions annually on unreproducible preclinical research
Study estimates $28 billion spent yearly on preclinical research that can’t be replicated
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OpinionMagic molecule modifiers
Late stage functionalisation can seem supernaturally powerful, says Derek Lowe – if you’ve got the nerve to try it
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ResearchTaking the lead on drug discovery
Making compounds that promise to become useful drugs has just become a little easier
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NewsRoadmap to reward pharma for creating new antibiotics unveiled
Report recommends large up-front payments and an innovation fund for blue skies research to tackle microbial resistance
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ReviewVenoms to drugs: venom as a source for the development of human therapeutics
Defanging chemistry
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ResearchZombie cells may rise up to kill infections
Bacteria killed by silver may act as vessels for the metal to kill other pathogens
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ResearchSiRNA treatment cures Ebola in monkeys
Researchers perform the first successful trial for a drug against the current strain of Ebola
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FeatureCombating rare diseases
Developing drugs for treating rare diseases isn’t always financially viable. Clare Sansom looks at some recent success stories
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OpinionBe careful what you wish for
Measuring R&D productivity is a thorny issue. Dennis Lendrem urges the pharmaceutical industry to learn from its mistakes.
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OpinionAnalogues by catalogue
Buying in screening compounds directly feels like cutting out the synthetic chemist middleman, says Derek Lowe
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Business23andMe jumps into drug R&D
Gene profiling firm aims to capitalise on its databank of genetic information to discover new drugs
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ResearchProgram ready to weed out tough drug leads
Model could help drug firms avoid synthetically complex dead ends and speed drug discovery
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FeatureFrom screen to cell
Nina Notman finds out how liquid crystals are moving into the biotechnology and pharmaceutical toolbox
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Business
Europe approves stem cell therapy
Treatment for burn-damaged eyes uses patient’s own scaffold-grown cells
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OpinionTantalising technology
Computer-assisted drug design always looks like it’s just about to work, says Derek Lowe, but the reality is complicated
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OpinionTarget ignorance to tackle resistance
Countries like India are bearing the brunt of antibiotic resistance, and education could be a key tool in tackling its spread