Drug formulation and delivery
The latest chemistry news and research on drug formulation and delivery, including encapsulation, controlled release and nanomedicine, from the Royal Society of Chemistry's magazine, Chemistry World
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ResearchTherapeutic proteins can hitch a ride on parasite to bypass blood-brain barrier
Toxoplasma could be delivery agent for protein drugs – provided parasite can be made safe
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ResearchDrugs and vaccines could be freed from cold chains by hydrogel
Stiff gel prevents proteins from aggregating, preserving their therapeutic power
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ResearchCould mechanochemistry have saved Abbott Laboratories $250 million?
Ball milling solves problem of disappearing ritonavir polymorph
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BusinessNovo Holdings to buy contract manufacturer Catalent for $16.5 billion
Parent firm will then sell on three manufacturing sites to Novo Nordisk to boost capacity for diabetes and weight loss drugs
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ResearchAntibiotic adjuvant designed to subvert bacterial defence mechanisms
Amphiphilic molecule helps obsolete antibiotics accumulate and act within bacteria
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OpinionCompounding problems
Regulating the line between a vital service and grey-market profiteering is a mess
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ResearchNew insights into polyamorphism could influence how drugs are formulated
Findings suggest dihedral angle distribution might explain why polyamorphs have different physical properties
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BusinessUK becomes first country in the world to authorise a Crispr-based gene therapy
Treatment aims to cure patients with β-thalassaemia and sickle-cell disease
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ResearchInsulin medicines more resilient to temperature than previously thought
Review suggests more lenient storage guidelines could make diabetes treatments more accessible
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BusinessTornado at Pfizer plant accentuates US drug shortage issues
Perennial problem will not be addressed without major reforms to drug market
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ArticleLight-activated molecular motor drives drug delivery
Drug-delivery system is a ‘step towards using molecular motors in the clinic’
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OpinionBringing drug manufacturing back home
Pharmaceutical supply chains are international, complex and opaque. Is there a better way?
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NewsAir jet gun delivers needle-free vaccines in MOFs without any need for refrigeration
Release rate of injector system can be fine-tuned by changing the carrier gas
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ResearchThe hunt is on for vaccine ingredients that don’t come from wild sharks
Yeast can provide the raw materials and chemical wizardry can transform them
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BusinessEncoding creativity in drug discovery
Machine learning can complement and reinforce human intuition and experience
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ArticleThermal analysis in the development of long-acting injectable systems
Evaluating new polymers for slow-release drug delivery could deliver better treatment for patients
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FeatureTiny delivery systems for cancer drugs
Encapsulating anticancer agents in nanoparticles can make them gentler on the rest of the body. Clare Sansom reports
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BusinessAn evolution in pharma outsourcing
Contract services firms are becoming increasingly sophisticated and embedded in the ecosystem of drug development
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NewsSoftware from Cambridge crystallographic experts could save pharma industry millions
Informatic tools will help drug formulators understand particle behaviour in their final product