Drug formulation and delivery – Page 5
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BusinessFit for repurpose
Drugs that can be used for new indications offer a potentially cheaper pathway – but only if the investors can recoup their costs
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ArticleIs industry ready for the serialisation shake-up?
The regulation few outside of pharma have heard about
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ArticleDriving pharmaceutical innovation
Making drugs is neither easy nor cheap – but catalysts, flow chemistry and a knowledge of intermolecular interactions can help
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ArticleDissolving insoluble drugs
How spray drying can help with solubility and bioavailability challenges in drug development
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FeatureThe chemistry of the microbiome
Our gut bacteria are carrying out chemistry on our behalf, but without us knowing much about it. Now, scientists are starting to examine their enzymes
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NewsIllegal antibiotic combinations threaten efforts to battle antimicrobial resistance
Unapproved formulations make up two-thirds of combination therapies sold in India
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FeatureArtificial blood
Nina Notman reports on progress towards products that can, when necessary, replace donor red blood cells
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BusinessDrug formula change infuriates French thyroid patients
Poor communication of changes to Merck KGaA’s levothyroxine has led to complaints of side effects
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ResearchResponsive nanoparticles target sight-stealing fungus
Eye drop tricks fungal eye infection into self-destruction
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FeatureDelivering gene therapy
After some well-publicised problems, gene therapy – delivering DNA into people’s cells using viruses – is booming, Anthony King finds
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ResearchBlue nanoparticles mop up radioactive element
Nanosized Prussian blue formulation removes radioactive caesium from body faster than commercial treatment
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FeatureIntracellular delivery
Drugs that can enter cells and take useful payloads with them are maturing, finds Andy Extance
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FeaturePersonalised skincare
Nina Notman explores some of the latest scientific approaches skincare companies are using in the quest to develop high-earning anti-ageing cosmetics
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ResearchDNA suitcases packed with gene therapy cargo
Nano-sized capsules can be unlocked to release drugs on demand
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ResearchConnectosomes smuggle drugs across membranes
Engineered vesicles could cut drug side-effects by delivering them straight into cells using cellular ‘airlocks’
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ResearchFreeze-dried cell parts for hassle-free molecule manufacturing
‘Just add water’ reaction pellets allow drugs and vaccines to be produced without special equipment or training
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OpinionHow to solve global health inequality
Our skills as scientists hold the answer, says the Bill & Melinda Gates Foundation
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ResearchMagnetic fields deliver cancer-killing bacteria to tumour’s heart
Guided microbes packed with drugs can reach the parts of cancers that other drugs just can’t reach
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ResearchKamikaze bacteria travel deep inside tumours to deliver deadly cargo
Engineered bacteria in tandem with chemotherapy show promise in mouse model of cancer
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ResearchMiniature carbon bottles hold promise as nano-reactors
Nanobubbles with hydrophobic interiors also have potential as drug delivery agents