In the pipeline from Derek Lowe – Page 9
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OpinionElevating enzymes
Enzymes have been giving chemists inferiority complexes since day one, says Derek Lowe. But there's no denying their potential
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OpinionFluorine fanatics
Some medicinal chemists can't get enough fluorines in their molecules. Derek Lowe explains the love-hate relationship
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OpinionWe need more surprises
Who's that asleep at the back? Don't be too quick to blame yourself when tedious talks and soporific seminars fail to inspire, says Derek Lowe
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OpinionThe 'blockbuster mentality’
Should companies focus on big markets and the blockbuster dream? The more modern approaches are not without risks, says Derek Lowe
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OpinionThe quiet comeback of 'combi-chem'
Derek Lowe investigates the comeback combinatorial chemistry has made in the field of drug discovery
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How much selectivity do you want?
Derek Lowe considers the quandaries of living in the age of the kinase
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Missing methods
Derek Lowe reminisces about lost laboratory techniques and wonders which will be next to go
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If something can’t go on, then it won’t
Derek Lowe looks into his crystal ball to see what the future of medicinal chemistry might be
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OpinionDeath by assay result
Derek Lowe wonders whether tagging molecules with fluorescent labels for assay is like tracking the members of a shoal of fish by tying each one to a whale
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How to be an organised scientist
Derek Lowe waxes lyrical about the joys of the electronic lab notebook
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Papers vs patents
Derek Lowe wonders whether peer-reviewed papers or patents are more reliable
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The sincerest form of flattery
Is the pharmaceutical industry churning out copycat versions of existing therapies? Derek Lowe dispels a few myths about 'me-too' drugs
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Senseless screening
Derek Lowe advises opening your mind during the screening cascade taken by potential drug targets, and remaining goal orientated at all times
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Reliable reactions
Derek Lowe discusses the problem of leaning too heavily on favourite reactions
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Difficult diseases to drug
Derek Lowe wonders why some diseases are easier to drug than others
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Beautiful chemistry
Derek Lowe considers what makes a good looking drug molecule - and how beauty is in the eye of the beholder
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Formulation chemist friction
Derek Lowe wonders where we'd be without the formulation chemists