Medicinal chemistry
The latest chemistry news and research on medicinal chemistry including drug discovery, clinical trials, toxicology and science of disease, from the Royal Society of Chemistry's magazine, Chemistry World
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ResearchCyclopropyl effect causes substituents on cyclohexane to favour axial conformation
‘Unusual stereocontrol element’ will help medicinal chemists increase three-dimensionality of drug candidates
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ResearchA new gold standard in selective nitrobenzene hydrogenation
Reaction proceeds through a previously unidentified mechanism
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NewsmicroRNA discovery wins Nobel prize in medicine
Research on tiny RNA molecules unlocked mysteries of gene regulation and cell differentiation
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BusinessUS approves schizophrenia drug with new mode of action
Cobenfy promises to better address negative symptoms than existing antipsychotics
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WebinarEmerging routes to new therapeutics: Highlights from winning Horizon Prize teams
Discover how new therapeutics have the potential to address unmet medical needs
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WebinarThe science and promise of liquid biopsies
Join us on 4 December to learn more about the science of liquid biopsies from leaders in the field
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OpinionA chemist in the flower garden
The beautifully complex molecules plants produce are as inspiring as the blooms themselves
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FeatureBlood biopsies for cancer
Testing small amounts of blood for the presence of disease markers could revolutionise how we detect cancer. Clare Sansom reports
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ResearchYellow food dye could give doctors a new way to look beneath the skin
Tartrazine can safely and reversibly turn the skin of mice transparent
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BusinessTea tree oil faces ban in UK and EU over reprotoxicity
Defenders question relevance of animal safety data that triggered decision
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BusinessUS industry braced for change as election looms
Regulation, trade tariffs and innovation support top lists of concerns
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OpinionBeing wrong is almost inevitable
On the tightrope of expressing your opinion, you always risk looking a fool
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OpinionGLP-1 drugs could be more than a win–win for weight loss
Semaglutide and tirzepatide are changing lives, and could change our attitudes
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FeatureThe GLP-1 weight loss revolution
Glucagon-like peptide-1 agonist drugs, such as semaglutide, could save countless lives at risk due to diabetes and obesity. Rachel Brazil looks at the difficulties in making the peptides themselves, and what’s coming next
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OpinionProteins’ shape and function are two sides of the same coin
A new perspective on the relationship between chemistry and biology
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BusinessMDMA rejection poses questions for psychedelic drug trials
Decision prompts reflection over how psychotherapy is involved, regulating combination treatments and safeguarding patients
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ResearchPotential new class of antibiotics takes on flesh-eating infections
Peptide-mimicking compounds target bacterial cell walls
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ResearchInnovative antibacterial strategy shows promise for treating infections
New antibiotic mechanism sees molecule infiltrate bacterial cells and destroy them from the inside
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ResearchAnalytical chemistry tools point to the future of personalised medical diagnostics
Molecular fingerprinting techniques outperform standard blood tests for detecting the onset of many diseases