Medicinal chemistry
The latest chemistry news and research on medicinal chemistry including drug discovery, clinical trials, toxicology and science of disease, from the Royal Society of Chemistry's magazine, Chemistry World
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OpinionMaintaining mental balance
Finding solace from human affairs in the eypiece of a telescope or microscope
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BusinessJ&J’s Intra-Cellular deal could signal more mega-mergers for 2025
£15 billion deal for neuroscience biotech aims to replace revenues from patent expiries
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OpinionSharing the burden of contraception could also mean sharing the risk
What if risk assessments for contraception considered the sum of risk to both members of a couple?
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FeatureOn the trail of the male contraceptive pill
As multiple novel male contraception compounds enter clinical trials, is family planning about to undergo a second revolution? James Mitchell Crow reports
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OpinionRobots queuing up to fail
Claims of an AI revolution in drug discovery are missing the biggest problem
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FeatureThe promise of drugs that send proteins to the shredder
Andy Extance charts how research into revolutionary targeted protein degradation therapies is moving from serendipity to strategic discovery
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ResearchFirst potential antidote for hydrogen sulfide poisoning created
A novel molecule can work as a multi-gas antidote providing potential treatment for carbon monoxide, cyanide and hydrogen sulfide poisoning
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ResearchAfter-school club students in Chicago discover promising bioactive compound via goose droppings
Chicago antibiotic discovery lab engages middle school students from underrepresented communities in hands-on research
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BusinessPharmaceuticals roundup 2024
Diabetes and weight loss drugs have surged in popularity, revealing supply frailties
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ResearchmRNA therapy might one day treat deadly pre-eclampsia in pregnant women
Therapy helped pregnant mice to regrow placental blood vessels
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ResearchAI tool learns to build molecules fragment by fragment
Software tasked with designing a type-II kinase inhibitor suggests 97 candidates in 10 minutes, three of which were both synthesisable and effective at micromolar and nanomolar concentrations
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BusinessEurope reconsiders Alzheimer’s antibody approval
Leqembi recommended for approval with restrictions to reduce side effect risk
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ResearchFirst detected 40 years ago, a byproduct in chloraminated drinking water has finally been identified
Researchers call for urgent investigation into the chloronitramide anion’s toxicity
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OpinionDo chemists die young?
Death notices for chemists suggest perhaps not, despite the hazards found in many labs
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ResearchCyclopropyl effect causes substituents on cyclohexane to favour axial conformation
‘Unusual stereocontrol element’ will help medicinal chemists increase three-dimensionality of drug candidates
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ResearchA new gold standard in selective nitrobenzene hydrogenation
Reaction proceeds through a previously unidentified mechanism
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NewsmicroRNA discovery wins Nobel prize in medicine
Research on tiny RNA molecules unlocked mysteries of gene regulation and cell differentiation
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BusinessUS approves schizophrenia drug with new mode of action
Cobenfy promises to better address negative symptoms than existing antipsychotics