Medicinal chemistry
The latest chemistry news and research on medicinal chemistry including drug discovery, clinical trials, toxicology and science of disease, from the Royal Society of Chemistry's magazine, Chemistry World
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Opinion
Fluorine makes you an offer you can’t refuse
What might we do if we had a new, electron-donating equivalent element?
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Research
Generative AI pipeline creates promising antimicrobial peptides
AI model extrapolates beyond training data to predict diverse antimicrobial structures
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Opinion
How natural nanomotors could propel new drug delivery systems
Biological cells including bacteria, sperm cells and microalgae show promise for precision treatments
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Business
New type of painkiller approved in US
Sodium channel blocker prevents nerves transmitting pain signals
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Feature
Putting the F in pharma
Adding fluorine to drug molecules can be tricky, but is often worthwhile. Rachel Brazil talks to the chemists trying to tame the ninth element
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Research
Far more drugs could be taken orally by formulating them with silica nanoparticles
Many more medicines could be made water soluble making taking them easier for patients
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Research
Mapping metabolite disturbances by drugs
High-throughput metabolomic profiling gives insight into unpredictable drug effects
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Research
Quick test could catch fatal tick fever before it’s too late
Lateral flow test diagnosed fatal disease in animal model before symptoms appeared
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Opinion
Maintaining mental balance
Finding solace from human affairs in the eypiece of a telescope or microscope
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Business
J&J’s Intra-Cellular deal could signal more mega-mergers for 2025
£15 billion deal for neuroscience biotech aims to replace revenues from patent expiries
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Opinion
Sharing the burden of contraception could also mean sharing the risk
What if risk assessments for contraception considered the sum of risk to both members of a couple?
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Feature
On the trail of the male contraceptive pill
As multiple novel male contraception compounds enter clinical trials, is family planning about to undergo a second revolution? James Mitchell Crow reports
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Opinion
Robots queuing up to fail
Claims of an AI revolution in drug discovery are missing the biggest problem
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Feature
The promise of drugs that send proteins to the shredder
Andy Extance charts how research into revolutionary targeted protein degradation therapies is moving from serendipity to strategic discovery
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Research
First potential antidote for hydrogen sulfide poisoning created
A novel molecule can work as a multi-gas antidote providing potential treatment for carbon monoxide, cyanide and hydrogen sulfide poisoning
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Research
After-school club students in Chicago discover promising bioactive compound via goose droppings
Chicago antibiotic discovery lab engages middle school students from underrepresented communities in hands-on research
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Business
Pharmaceuticals roundup 2024
Diabetes and weight loss drugs have surged in popularity, revealing supply frailties
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Research
mRNA therapy might one day treat deadly pre-eclampsia in pregnant women
Therapy helped pregnant mice to regrow placental blood vessels
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