Medicinal chemistry
The latest chemistry news and research on medicinal chemistry including drug discovery, clinical trials, toxicology and science of disease, from the Royal Society of Chemistry's magazine, Chemistry World
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News
Fears grow over the future of mRNA vaccine research in the US
Researchers working on mRNA vaccines fear federal funding might be halted, with many looking to move projects abroad
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Business
Acceptable levels of (epi)genetic engineering
Amplifying or silencing genes may be preferable to permanently changing genetic code
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Research
Rare disease drug can make human blood toxic to mosquitoes
Insect enzyme inhibitor could help control malaria
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Business
Epigenetic editors enter clinical trials
New wave of precision medicines amplify or silence genes, without altering genetic code
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Business
US regulatory chief’s resignation raises alarms in biotech industry
FDA vaccines and biologicals centre director, Peter Marks, clashed with health secretary Robert F Kennedy Jr
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Opinion
Welcome to the MegaPharm target selection and project resourcing meeting
Overheard recently in a seminar room near you…
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Opinion
Weight loss drug supply races
With official shortages ended, but the first generics gearing up for launch, companies are looking for the next generation of drugs
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Research
Skeletal editing targets double bonds
Two new techniques selectively install nitrogen atoms into complex molecules
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Business
Ending of US weight-loss drug shortages prompts compounder complaints
Decision ends pharmacies’ permission to prepare versions of GLP-1 hormone mimics
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Opinion
Fluorine makes you an offer you can’t refuse
What might we do if we had a new, electron-donating equivalent element?
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Research
Generative AI pipeline creates promising antimicrobial peptides
AI model extrapolates beyond training data to predict diverse antimicrobial structures
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Opinion
How natural nanomotors could propel new drug delivery systems
Biological cells including bacteria, sperm cells and microalgae show promise for precision treatments
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Business
New type of painkiller approved in US
Sodium channel blocker prevents nerves transmitting pain signals
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Feature
Putting the F in pharma
Adding fluorine to drug molecules can be tricky, but is often worthwhile. Rachel Brazil talks to the chemists trying to tame the ninth element
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Research
Far more drugs could be taken orally by formulating them with silica nanoparticles
Many more medicines could be made water soluble making taking them easier for patients
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Research
Mapping metabolite disturbances by drugs
High-throughput metabolomic profiling gives insight into unpredictable drug effects
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Research
Quick test could catch fatal tick fever before it’s too late
Lateral flow test diagnosed fatal disease in animal model before symptoms appeared
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Opinion
Maintaining mental balance
Finding solace from human affairs in the eypiece of a telescope or microscope
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Business
J&J’s Intra-Cellular deal could signal more mega-mergers for 2025
£15 billion deal for neuroscience biotech aims to replace revenues from patent expiries
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Opinion
Sharing the burden of contraception could also mean sharing the risk
What if risk assessments for contraception considered the sum of risk to both members of a couple?