Medicinal chemistry
The latest chemistry news and research on medicinal chemistry including drug discovery, clinical trials, toxicology and science of disease, from the Royal Society of Chemistry's magazine, Chemistry World
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BusinessUS regulatory chief’s resignation raises alarms in biotech industry
FDA vaccines and biologicals centre director, Peter Marks, clashed with health secretary Robert F Kennedy Jr
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OpinionWelcome to the MegaPharm target selection and project resourcing meeting
Overheard recently in a seminar room near you…
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OpinionWeight loss drug supply races
With official shortages ended, but the first generics gearing up for launch, companies are looking for the next generation of drugs
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ResearchSkeletal editing targets double bonds
Two new techniques selectively install nitrogen atoms into complex molecules
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BusinessEnding of US weight-loss drug shortages prompts compounder complaints
Decision ends pharmacies’ permission to prepare versions of GLP-1 hormone mimics
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OpinionFluorine makes you an offer you can’t refuse
What might we do if we had a new, electron-donating equivalent element?
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ResearchGenerative AI pipeline creates promising antimicrobial peptides
AI model extrapolates beyond training data to predict diverse antimicrobial structures
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OpinionHow natural nanomotors could propel new drug delivery systems
Biological cells including bacteria, sperm cells and microalgae show promise for precision treatments
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BusinessNew type of painkiller approved in US
Sodium channel blocker prevents nerves transmitting pain signals
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FeaturePutting the F in pharma
Adding fluorine to drug molecules can be tricky, but is often worthwhile. Rachel Brazil talks to the chemists trying to tame the ninth element
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ResearchFar more drugs could be taken orally by formulating them with silica nanoparticles
Many more medicines could be made water soluble making taking them easier for patients
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ResearchMapping metabolite disturbances by drugs
High-throughput metabolomic profiling gives insight into unpredictable drug effects
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ResearchQuick test could catch fatal tick fever before it’s too late
Lateral flow test diagnosed fatal disease in animal model before symptoms appeared
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OpinionMaintaining mental balance
Finding solace from human affairs in the eypiece of a telescope or microscope
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BusinessJ&J’s Intra-Cellular deal could signal more mega-mergers for 2025
£15 billion deal for neuroscience biotech aims to replace revenues from patent expiries
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OpinionSharing the burden of contraception could also mean sharing the risk
What if risk assessments for contraception considered the sum of risk to both members of a couple?
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FeatureOn the trail of the male contraceptive pill
As multiple novel male contraception compounds enter clinical trials, is family planning about to undergo a second revolution? James Mitchell Crow reports
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OpinionRobots queuing up to fail
Claims of an AI revolution in drug discovery are missing the biggest problem
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FeatureThe promise of drugs that send proteins to the shredder
Andy Extance charts how research into revolutionary targeted protein degradation therapies is moving from serendipity to strategic discovery
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ResearchFirst potential antidote for hydrogen sulfide poisoning created
A novel molecule can work as a multi-gas antidote providing potential treatment for carbon monoxide, cyanide and hydrogen sulfide poisoning