Medicinal chemistry – Page 12
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ResearchSulfonated macrocycle helps the medicine go down
A supramolecular approach makes alkaloid drugs taste less bitter
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ResearchArray of compounds found in plastics promote fat cell formation in vitro
A third of thousands of chemicals that leach from consumer polymers linked to the development of fat cells
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BusinessTrials start of mRNA vaccine for HIV
First steps towards protection from the many and variable viral strains
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ResearchLeft-handed nanoparticles are far better vaccine adjuvants than their mirror images
Chiral gold nanoparticles shown for the first time to elicit differing immune responses in cells and live mice
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NewsExplainer: How do the Covid vaccines measure up against each other and omicron?
Looking at how the evidence stacks up for vaccines against variants and how their performance holds up over time
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OpinionLetters: February 2022
Readers investigate June Lindsey’s legacy, question policy and celebrate vaccination
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OpinionThe shadow of drug resistance
Why do some medicines stop working, and can we avoid it for Covid-19 antivirals?
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BusinessMartin Shkreli fined and banned from pharma for life
‘Pharma Bro’ must pay back $65m in profits for anticompetitive behaviour while leading Turing Pharmaceuticals
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OpinionThe law of conservation of data
AI and machine learning are useful and powerful, but they need high quality data inputs that aren’t available yet for drug discovery
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ResearchGreen credentials of crystallisation process turned around by rotary cone dryer tweak
Mechanochemistry helps transformations and cocrystallisations cut solvent use on an industrial scale
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OpinionWhen regulatory cooperation goes too far, we all lose
Were FDA staff unduly influenced by Biogen in approving Alzheimer’s antibody?
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BusinessPharmaceuticals roundup 2021
It’s been another dramatic, pandemic-dominated year for the pharmaceutical industry
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WebinarUsing flow chemistry to give early drug discovery processes a boost
Discover how pioneering modular flow chemistry technologies can unlock the potential for discovery chemists to accelerate research
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ResearchEngineered antibody that snags sperm could be an effective non-hormonal contraceptive
Approach could offer new method of contraception for women
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ResearchProkaryotes programmed to produce paracetamol avoid pervasive petrochemicals
Genetically modified E. coli serve as green factories for painkillers
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BusinessPfizer sues former employee for alleged trade secret theft
Chun Xiao Li downloaded thousands of confidential documents before resigning
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BusinessCovid-19 antivirals surge forward
Promising results from Pfizer trial, while UK approves Merck & Co’s molnupiravir
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ResearchGallium helps sneak antibiotic payload into bacterial cells
Compound is more potent than parent drug ciprofloxacin against Staphylococcus aureus
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OpinionTaking the right inspiration from nature
Scientists need to be selective about their sources of inspiration
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FeaturemRNA vaccines for Covid and beyond
Already hailed as a miracle, the new vaccine technology could protect us from other diseases, Clare Sansom finds