Medicinal chemistry – Page 12
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BusinessCalifornia advances plans to make its own insulin
Governor commits $100 million to develop low-cost insulin and build manufacturing facility to strengthen drug’s supply chain
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BusinessSecond Theranos executive convicted of fraud
Blood testing startup president Ramesh ‘Sunny’ Balwani defrauded both investors and patients
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OpinionAlzheimer’s, amyloid and abandoned antibodies
Biogen’s aducanumab is stumbling into obscurity. Where does that leave the amyloid hypothesis?
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ResearchMolecular machine drills holes in antibiotic-resistant bacteria killing them
Bacteria aren’t able to develop resistance against nanomotor’s deadly action
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NewsNew questions raised over Sputnik Covid vaccine results point to fraudulent practices
Analysis comparing Sputnik results with five other Covid vaccines finds phase 3 trial outcome is highly improbable
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ResearchEncapsulated bacteria show promise as injectable living drugs factories to treat diseases
Engineered E. coli produce insulin and vaccines in vivo
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BusinessSoapbark branches out to fill essential role in vaccine recipes
The soapbark tree has long been used in traditional medicines, but is now coveted for some of our newest vaccines
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FeatureUsing genetics to personalise prescriptions
We’ve known for a long time that different people respond to certain drugs to very different extents, but now cheap DNA testing could make these disparities a thing of the past, as Ian Le Guillou reports
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ResearchLight-activated cancer treatment uses tumour-targeting enzymes to cut side effects
Enzymatic activation of a photosensitive prodrug in cancerous cells shows promise in mice
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ResearchBreaking bacteria’s genetic silence to synthesise antibiotics that evade resistance
Prospecting in bacterial genomes offers hope in search for new antimicrobial drugs
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ResearchGut microbiome analysis spots sleep-deprived mice
Fluorescence-based sensing array that identifies bacteria in stool samples could be developed into a tool for diagnosing various conditions
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BusinessWhat is the future of Covid-19 pharmaceuticals?
Firms anticipate long-term markets for prevention and treatment
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ResearchCancer progression and harmful bacteria tracked with next-generation sequencing
Proof-of-principle study keeps an eye on leukaemia mutations and bacterial strains in patients
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FeatureThe incredible antibodies of sharks, llamas and camels
Sharks and llamas share a strange quirk of their immune systems. Hayley Bennett finds out how their ‘nanobodies’ could help us tackle Covid and a host of other diseases
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ResearchYeast engineered to convert methanol into heparin
Production levels are currently low, but researchers hope the method could one day mean pharma doesn’t have to rely on animals for this essential medicine
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ResearchAI tool finds green ways to turn chemical waste into drugs
Circular approach for industry by-products considers environmental, economic and geographic aspects to rank predicted routes for real-world applications
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ResearchEdible, fluorescent silk tags could help stem tide of counterfeit medicines
Marker could be a simple answer to ensuring provenance of drugs
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WebinarSpeed up process development by making more from your offline and online data
Learn how the biotechnology R&D team at Clariant uses statistical modelling techniques to speed up the process development of their bio-ethanol product
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ResearchPepto-Bismol compound’s structure unveiled after 120 years
Electron microscopy triumphed over x-ray crystallography as century-old structural puzzle around bismuth subsalicylate is finally solved