Medicinal chemistry – Page 14
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BusinessBudget cuts at UK medicines regulator raise eyebrows
MHRA to cut 300 jobs amid financial pressures arising from Brexit
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NewsResearch and regulations face-up to a new era of non-animal testing alternatives
Hopes raised that approval for skin sensitisation test could mark the start of a raft of in vitro toxicity tests
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BusinessBrewing up plant-inspired medicines
Antheia reconstructs complex biochemical pathways in yeasts to speed up production of natural product-based drugs
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ResearchNeural network scours vast chemical space to design drug-delivering peptides
Oligonucleotide drug activity boosted 50-fold with peptide designed by machine learning algorithm
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BusinessDeveloping countries sidelined in Covid-19 vaccine scramble
Lack of funds and local manufacturing capacity has prevented Covax from competing with wealthier nations’ self-interest
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ArticlePeptones: over 100 years of life-saving innovation
After a century, peptones continue to play a vital role in biopharmaceutical innovation
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FeatureHow the power of smell could identify new medical tests
Diagnosis by odour is nothing to be sniffed at, finds Ian Le Guillou
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BusinessPfizer backs protein degrader drugs with Arvinas deal
$1bn investment to commercialise breast cancer treatment
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WebinarHarness the power of electricity to make organic compounds
Join us to learn how to use batch-type cells in preparatory electrosynthesis
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BusinessNon-animal test for skin sensitisation gets OECD approval
Combination strategy developed by BASF and Givaudan is the first complete replacement for animal testing
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FeatureOne hundred years of insulin
Mike Sutton looks at the journey the diabetes treatment took from the Toronto miracle to mass-production – via a controversial trip to Stockholm
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ResearchElectrochemical DNA on a chip sensor detects bacterial urinary tract infections faster
Synthetic nucleic acid probes combine with tiny star-shaped electrodes tests for bacteria in less than an hour
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OpinionOpening up a cellular black box
Working out how biomolecular condensates work may reveal a lot about the success or failure of different drugs
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BusinessSartan contaminant recall hits generics manufacturers
Three European suppliers recalling multiple batches of medicines owing to active ingredient contamination
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NewsRace to understand Sars-CoV-2 variants amid fears virus might evade vaccines
Biochemical basis behind coronavirus variants’ success could hold key to defeating them
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BusinessBMS and Eisai agree antibody-drug conjugate commercialisation deal
Companies will jointly develop cancer treatment, with BMS paying up to $3 billion for shared rights
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FeatureSupermetals versus superbugs
With pathogenic bacteria rapidly overcoming our arsenal of organic antibiotics, James Mitchell Crow asks if it is time to revisit metal-based antimicrobials
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BusinessRegeneron’s Covid-19 antibodies help those who can’t make their own
Regn-Cov2 reduces deaths and shortens hospitalisation for these patients, even when given at late stages of infection
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ResearchBlocking bacteria’s self-poisoning mechanism weakens their antibiotic resistance
Stopping bacteria from producing hydrogen sulfide in response to drugs could help overcome antimicrobial resistance
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BusinessAlzheimer’s antibody gets surprise US approval
Good news for industry and future drug approvals, but physicians doubt it will be effective for most patients