Medicinal chemistry – Page 20
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ArticleAI and digital simulation for better medicines, made faster
Revolutionising pharma with next-generation technology to optimise and accelerate drug production processes
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ReviewBiography of Resistance: The Epic Battle Between People and Pathogens
A book illustrating a global health threat more daunting than Covid-19: growing antibiotic resistance
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OpinionThe ins and outs of vaccine trials
Derek Lowe lays out how the trials work, and why they get paused and restarted
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OpinionA promising peep at Covid-19 vaccine efficacy
Pfizer–BioNTech’s will need to be one of many if we are to overcome the pandemic
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BusinessEarly indications suggest Pfizer–BioNTech’s Covid-19 vaccine is effective
Company claims 90% efficacy at preventing disease, but experts call for data rather than press releases
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ResearchNanoparticle can starve aggressive breast cancer cells of vital copper
A new engineered particle depletes copper from mitochondria, killing breast cancer cells in mice
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NewsPandemic risks lost generation of junior scientists as charitable funding dries-up
Survey finds coronavirus, Brexit and lack of opportunities is forcing early career researchers backed by medical charities to consider alternative professions
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PodcastGlycyrrhizic acid
A sweet treat with a deadly trick for Halloween – glycyrrhizic acid is found in black liquorice and sweeter than sucrose, but can cause heart problems and even prove fatal if consumed in excess
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OpinionEthical challenge
Should researchers infect healthy people with Sars-CoV-2 to speed up vaccine testing?
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FeatureEngineering a handshake for proteins
Once considered undruggable, chemists are beginning to grasp protein–protein interactions, according to Ian Le Guillou
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ResearchPeptides self-assemble to support growth of artificial tumours
Cancer cells grown around bioengineered microfibres make an ideal model to test new chemotherapy drugs
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ResearchFast-acting insecticide polymorph could boost malaria-control efforts
Recrystallised deltamethrin accelerates uptake in mosquitoes
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NewsFirst Covid-19 challenge study working with live virus planned for the UK
Pending ethics panel approval, healthy volunteers would be infected with Sars-CoV-2 to help understand disease and test vaccines
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ResearchSalt bridge strategy expands access to pharmaceutical cocrystals
New approach to cocrystallisation could lead to exciting multi-drug combinations
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PodcastSofosbuvir
The hepatitis C drug that made waves when first launched – quicker to work and with fewer side effects than existing drugs, but it came with a hefty price tag
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NewsChemistry at work in e-liquids is still poorly understood, worrying researchers
New compounds with potentially harmful effects on the lungs can form from the mixture of flavours and solvents – even at room temperature
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NewsNew Covid-19 test doesn’t need reagents that are in short supply
US researchers develop a two-step test for the novel coronavirus that doesn’t requires the use of scarce reagents
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PodcastBedaquiline
The first TB drug approved in 40 years gave hope to sufferers of drug resistant tuberculosis and ushered in a new class of antibiotics
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OpinionBlood offering
Antibodies in various forms could bridge the Covid-19 treatment gap until a vaccine is available
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OpinionJumping the vaccine queue
Deals between companies and rich governments offset manufacturing risks, but must not compromise supplies to those in need