Medicinal chemistry – Page 21
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BusinessScrambling and gambling to scale up Covid-19 medicines
Organisations work towards making billions of doses of products not yet proven to work
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OpinionDragons of immunology
Anti-inflammatories like dexamethasone are triumphs amid the pitfalls of the immune system
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ResearchComputational method challenges NMR metabolomics dogma
Macromolecule signal suppression without the loss of quantitative small molecule information finally achieved with mathematical trick
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NewsExplainer: how is the vaccine pipeline for Covid-19 looking?
The race to develop a vaccine is almost six months old. Who’s in the lead?
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PodcastDexamethasone
News that this cheap, ubiquitous steroid drug may reduce deaths in Covid-19 cases has been greeted with cautious optimism
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NewsCovid-19 is forcing pharma to rethink clinical trials
Drug trials have become a casualty of Covid-19, but the pandemic is also prompting change
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OpinionMaking the right call on dexamethasone
The way we do things in research has to change in life or death situations
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WebinarWL Gore: Optimising production processes with Design of Experiments
Learn how WL Gore use definitive screening designs to analyse multiple factors and optimise production processes
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ResearchUnprecedented biosynthetic transformation found to connect antibacterial polyketides from ant microbiome
Study identifies enzymes that convert flat fasamycins into three-dimensional formicamycins
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ResearchAlgorithm devises synthetic contingency plans for Covid-19 drug
Retrosynthesis software tool can identify multiple synthetic routes that use inexpensive and diverse starting materials while avoiding patented methods
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NewsCaution urged as scientists await results of trial that finds steroid cuts Covid-19 deaths
Claims that 60-year-old drug dexamethasone dramatically lowers fatality rate of seriously ill Covid-19 patients await peer review
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FeatureThe difficulties of drugging our brains
Following the withdrawal of many large pharma companies from central nervous system research, Andy Extance finds new drug development patterns are emerging
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PodcastCimetidine
Mike Freemantle introduces the peptic ulcer treatment cimetidine, which – as Tagamet – became the first blockbuster drug
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ResearchMethod that yields oxygen-18-enriched alcohols set to bolster drug studies
Mitsunobu-based protocol is simple alternative to limited and lengthy methods
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OpinionCollaboration is key to AI-aided drug discovery
The AI Cures project shows how artificial intelligence can assist the search for a cure for Covid-19
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ResearchRespiratory viruses detected in 30 minutes with the help of a smartphone
$50 smartphone accessory could be adapted for Covid-19
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BusinessDeveloping antiviral mask technology in a pandemic
Surface chemistry strategies play a pivotal role in personal protective equipment that can neutralise the Sars-CoV-2 virus
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ArticleOptimising biotech processes
Fujifilm Diosynth Biotechnologies achieve both speed and scale through designed experiments
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PodcastFexinidazole
The World Health Organisation hope to eradicate sleeping sickness within our lifetimes. Jamie Durrani looks at a drug that may make it possible.
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ResearchDatabase offers another way to search for drugs – by activity not structure
Dataset offers new way for biomedical researchers to identify potential drug candidates