Medicinal chemistry – Page 25
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BusinessCancer and rare diseases dominated 2019 drug approvals
More streamlined review processes and changing R&D priorities have contributed to sustained increase in new medicines
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BusinessResearchers call for stricter rules on drug-like medical devices
More oversight is needed over products in the grey area between medical device and medication
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OpinionStartup EQRx claims it can revolutionise drug discovery
If it can deliver reasonable drugs at knock-down prices, will providers be convinced?
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ResearchSugars designed to disrupt bacterial cell wall biosynthesis
Rare monosaccharides explore concept for new narrow-spectrum antibiotics
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WebinarRenewable resources: the future role of lignins
Learn how to gain more detailed insight into your lignin samples with Antje Potthast from Waters
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ResearchSynthetic strategy exploits fluxional nitrogen to deliver three chiral centres for the price of one
Innovative method amplifies chirality and complexity in medicinally relevant cyclic hydrazines
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ResearchE-liquids linked to US deaths form deadly compound when vaped
Pyrolysis of vitamin E acetate creates organic molecule with effects comparable to first world war chemical weapon
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BusinessRevived Alzheimer’s antibody met with guarded optimism
Biogen’s aducanumab offers the possibility to slow disease progress, but regulators will likely want more convincing evidence
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ResearchCompact pharmaceutical factory manufactures drugs on demand
Plant with modular design would occupy about half the area of a squash court
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ResearchInorganic fragment library ready to help drug discoverers reach neglected regions of chemical space
A new approach to fragment-based drug design
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NewsPoor antibiotic stewardship blamed as India found to be superbug’s birthplace
Spread of superbugs a growing problem for the subcontinent
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ResearchTotal synthesis of H. pylori antigen creates starting point for gastric cancer vaccine
Remote participation strategy helps chemists make sterically-congested repeating fragment
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FeatureCan smart biomaterials deliver?
James Mitchell Crow explores the next generation of therapeutic biomaterials, which aim to interact dynamically with the body and help to control diabetes and heal wounds
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PodcastIminosugars
After some promising results treating ill pets, some researchers think iminosugars could become treatments for infection and even cancer. Mike Freemantle explores the buzz around iminohoney
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BusinessPharmaceuticals roundup 2019
Under the shadow of political turmoil and major lawsuits, the industry returned to its strengths – making new drugs, and finding new ways to do it better
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PodcastOxycodone and hydrocodone
Frances Addison examines how our quest to control and manage pain has led to a modern medical crisis, as opioids oxycodone and hydrocodone are among the most abused prescription medications in the US
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ReviewSuperbugs: The Race to Stop an Epidemic
A doctor’s story about his fight against drug-resistant microbes that threaten the future of medicine
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ResearchSpectroscopic biomarkers track Huntington’s disease progression
Analysis recognises biochemical changes that are unique to Huntington’s
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ResearchEngineered insulin with enhanced thermal stability inspired by fish-hunting snails
Four-disulfide insulin has similar bioactivity to native human insulin
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OpinionCleaning up chemical kitchens
In a busy plant, ensuring small changes don’t produce unforeseen toxic impurities is key