Medicinal chemistry – Page 26
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NewsEuropean commission gives green light to first Ebola vaccine
Drug shown to be effective and safe following clinical trials involving 16,000 people
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ArticleArtificial intelligence: on the cusp of a digital revolution
AI is transforming the pharma industry and its drug discovery pipeline
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ResearchFlow synthesis produces chiral intermediate for antidepressant drug
The first solvent-free organocatalytic flow process yields the key chiral intermediate for paroxetine on a multigram-scale
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NewsSwipe right to help in the fight against Huntington’s disease
Citizen science project improves understanding of protein misfolding disorders like Huntington’s and Alzheimer’s diseases
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FeatureSeparating turmeric fact from fiction
Thousands of papers have been published on curcumin’s healing potential, but its usefulness is not yet proven, finds Andy Extance
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OpinionWill computers ever discover drugs from scratch?
With enough understanding and computing power, it should be possible, but will it happen?
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WebinarAdvantages of characterising pharmaceuticals using DSC and TGA
Learn how APIs, excipients and formulations can be investigated by differential scanning calorimetry and thermogravimetric analysis
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WebinarAI and deep learning for chemistry with Pipeline Pilot
Learn how teams can effectively collaborate, manage and implement machine learning using Pipeline Pilot from Dassault Systèmes
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NewsStudy claiming gene-edited babies were more likely to die young was wrong
Database bias introduced major error in a now retracted study on Crispr babies’ mortality
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PodcastHypoxia-inducible factors – HIFs
The oxygen sensors that help life react to changing conditions, key to the 2019 Nobel prize in physiology or medicine
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BusinessThe rise of venture philanthropy
More and more charities are investing in companies, and looking for returns on that investment, as an alternative to traditional grants
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PodcastCiguatoxin
The toxin found in reef fish that leads to food poisoning so bad it can cause life-long symptoms
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RSCThe future of chemistry: Science Horizons and Chemistry Means Business
Hundreds of scientists contributed to the Royal Society of Chemistry’s Science Horizons report to build a picture of the challenges and opportunities the next generation will bring
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ResearchAlzheimer’s therapy has click chemistry use, then remove, brain copper build-ups
In situ drug synthesis catalysed by endogenous copper
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ResearchMetallohelices emulate antimicrobial peptides
Scientists move away from traditional drug candidates to evade resistance
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BusinessSixth in a line of Alzheimer’s drugs fails in trials
Treatments designed to stop amyloid peptide formation all seem to cause cognitive impairment rather than prevent it
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ArticleThe importance of solid form science in modern drug development
A recent study suggests that around 40% of drugs with market approval exhibit poor water solubility and although this is not a new problem, solutions like those offered by Johnson Matthey are still relevant to today’s pharma market
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OpinionUnder a cloud
Chemical detective work is needed to track down what’s been killing e-cigarette users