Medicinal chemistry – Page 26
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OpinionTwo heads are better than one
Bifunctionals show that sometimes simply tethering two useful molecules together unlocks some useful activity
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FeatureAdjuvants: vaccines’ hidden helpers
Anthony King examines a crucial part of vaccines that can significantly boost their performance, but which often go unrecognised
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BusinessThe race to fight coronavirus
While genome sequences enable testing and vaccine efforts, companies are donating existing antiviral drugs to explore repurposing
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ArticleTransforming innovation for startups
Green polymer specialists Novomer and biotech startup SynbiCite optimised industrial and biotech processes using design of experiment software from JMP
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ResearchChemists complete synthesis of molecule ‘at the limits of complexity’
Synthesis of canataxpropellane paves the way to biological studies
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ResearchFirst Crispr cancer trial in humans shows safety and durability
Immune-cell modifications target tumours and lift the PD-1 ‘brake’
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ResearchTest for antibiotic resistance genes provides answers within an hour
Whole blood method for diagnosing bacterial infections has unprecedented speed and sensitivity
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ResearchWarning that 3D printing pills can stop drugs working
Photoreactive monomers need close scrutiny for production of polypills
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FeatureThe search for cancer vaccines
Claire Jarvis looks at ongoing work to prevent the disease – and convince a sceptical community of their seriousness
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OpinionThe hunt for a killer stalking vapers
Vaping deaths in the US became a whodunnit as chemistry was called upon to track down the culprit
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BusinessCancer and rare diseases dominated 2019 drug approvals
More streamlined review processes and changing R&D priorities have contributed to sustained increase in new medicines
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BusinessResearchers call for stricter rules on drug-like medical devices
More oversight is needed over products in the grey area between medical device and medication
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OpinionStartup EQRx claims it can revolutionise drug discovery
If it can deliver reasonable drugs at knock-down prices, will providers be convinced?
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ResearchSugars designed to disrupt bacterial cell wall biosynthesis
Rare monosaccharides explore concept for new narrow-spectrum antibiotics
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WebinarRenewable resources: the future role of lignins
Learn how to gain more detailed insight into your lignin samples with Antje Potthast from Waters
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ResearchSynthetic strategy exploits fluxional nitrogen to deliver three chiral centres for the price of one
Innovative method amplifies chirality and complexity in medicinally relevant cyclic hydrazines
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ResearchE-liquids linked to US deaths form deadly compound when vaped
Pyrolysis of vitamin E acetate creates organic molecule with effects comparable to first world war chemical weapon
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BusinessRevived Alzheimer’s antibody met with guarded optimism
Biogen’s aducanumab offers the possibility to slow disease progress, but regulators will likely want more convincing evidence
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ResearchCompact pharmaceutical factory manufactures drugs on demand
Plant with modular design would occupy about half the area of a squash court
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ResearchInorganic fragment library ready to help drug discoverers reach neglected regions of chemical space
A new approach to fragment-based drug design