Medicinal chemistry – Page 27
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ResearchInorganic fragment library ready to help drug discoverers reach neglected regions of chemical space
A new approach to fragment-based drug design
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NewsPoor antibiotic stewardship blamed as India found to be superbug’s birthplace
Spread of superbugs a growing problem for the subcontinent
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ResearchTotal synthesis of H. pylori antigen creates starting point for gastric cancer vaccine
Remote participation strategy helps chemists make sterically-congested repeating fragment
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FeatureCan smart biomaterials deliver?
James Mitchell Crow explores the next generation of therapeutic biomaterials, which aim to interact dynamically with the body and help to control diabetes and heal wounds
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PodcastIminosugars
After some promising results treating ill pets, some researchers think iminosugars could become treatments for infection and even cancer. Mike Freemantle explores the buzz around iminohoney
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BusinessPharmaceuticals roundup 2019
Under the shadow of political turmoil and major lawsuits, the industry returned to its strengths – making new drugs, and finding new ways to do it better
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PodcastOxycodone and hydrocodone
Frances Addison examines how our quest to control and manage pain has led to a modern medical crisis, as opioids oxycodone and hydrocodone are among the most abused prescription medications in the US
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ReviewSuperbugs: The Race to Stop an Epidemic
A doctor’s story about his fight against drug-resistant microbes that threaten the future of medicine
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ResearchSpectroscopic biomarkers track Huntington’s disease progression
Analysis recognises biochemical changes that are unique to Huntington’s
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ResearchEngineered insulin with enhanced thermal stability inspired by fish-hunting snails
Four-disulfide insulin has similar bioactivity to native human insulin
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OpinionCleaning up chemical kitchens
In a busy plant, ensuring small changes don’t produce unforeseen toxic impurities is key
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NewsEuropean commission gives green light to first Ebola vaccine
Drug shown to be effective and safe following clinical trials involving 16,000 people
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ArticleArtificial intelligence: on the cusp of a digital revolution
AI is transforming the pharma industry and its drug discovery pipeline
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ResearchFlow synthesis produces chiral intermediate for antidepressant drug
The first solvent-free organocatalytic flow process yields the key chiral intermediate for paroxetine on a multigram-scale
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NewsSwipe right to help in the fight against Huntington’s disease
Citizen science project improves understanding of protein misfolding disorders like Huntington’s and Alzheimer’s diseases
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FeatureSeparating turmeric fact from fiction
Thousands of papers have been published on curcumin’s healing potential, but its usefulness is not yet proven, finds Andy Extance
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OpinionWill computers ever discover drugs from scratch?
With enough understanding and computing power, it should be possible, but will it happen?
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WebinarAdvantages of characterising pharmaceuticals using DSC and TGA
Learn how APIs, excipients and formulations can be investigated by differential scanning calorimetry and thermogravimetric analysis
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WebinarAI and deep learning for chemistry with Pipeline Pilot
Learn how teams can effectively collaborate, manage and implement machine learning using Pipeline Pilot from Dassault Systèmes