Medicinal chemistry – Page 28
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PodcastHypoxia-inducible factors – HIFs
The oxygen sensors that help life react to changing conditions, key to the 2019 Nobel prize in physiology or medicine
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BusinessThe rise of venture philanthropy
More and more charities are investing in companies, and looking for returns on that investment, as an alternative to traditional grants
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PodcastCiguatoxin
The toxin found in reef fish that leads to food poisoning so bad it can cause life-long symptoms
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RSCThe future of chemistry: Science Horizons and Chemistry Means Business
Hundreds of scientists contributed to the Royal Society of Chemistry’s Science Horizons report to build a picture of the challenges and opportunities the next generation will bring
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ResearchAlzheimer’s therapy has click chemistry use, then remove, brain copper build-ups
In situ drug synthesis catalysed by endogenous copper
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ResearchMetallohelices emulate antimicrobial peptides
Scientists move away from traditional drug candidates to evade resistance
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BusinessSixth in a line of Alzheimer’s drugs fails in trials
Treatments designed to stop amyloid peptide formation all seem to cause cognitive impairment rather than prevent it
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ArticleThe importance of solid form science in modern drug development
A recent study suggests that around 40% of drugs with market approval exhibit poor water solubility and although this is not a new problem, solutions like those offered by Johnson Matthey are still relevant to today’s pharma market
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OpinionUnder a cloud
Chemical detective work is needed to track down what’s been killing e-cigarette users
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ResearchElusive protein and key to many tropical diseases found after decades of searching
Discovery offers powerful new target to treat trypanosome parasite illnesses that affect millions
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PodcastSodium fluoroacetate
The controversial killer compound – also known as 1080 – being used to protect New Zealand’s native wildlife
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OpinionEmbracing structural disorder
Medicinal chemists need to overcome their fear of fuzzy proteins
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NewsUS children’s hospital takes delivery of one of world’s most powerful NMR spectrometers
Instrument offers unprecedented opportunities to study disease development
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NewsDeaths from vaping-linked lung disease in US connected to vitamin E additive
Tocopheryl acetate implicated in 380 cases of severe lung disease and six deaths
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ReviewMescaline: A Global History of the First Psychedelic
A story about the people who harvested, used, abused, regulated and investigated the mind-altering drug
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FeatureStem cell hype
Many clinics around the world offer unproven treatments, while genuine therapies are slowly making their way through trials. Anthony King reports
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PodcastDomoic acid
The marine toxin that drives animals crazy and might have inspired one of Alfred Hitchcock’s most famous films
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PodcastBoric acid
Mike Freemantle revisits battlefield surgery to investigate boric acid, a key part of Dakin's antiseptic solution used extensively in the first world war