Medicinal chemistry – Page 29
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ResearchRetrosynthetic algorithm broadened to design similar, but different, molecules
Chematica can now design efficient syntheses for large compound libraries
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PodcastAmygdalin & Laetrile
Patrick Hughes delves into the molecule at the centre of a decades-old cancer treatment conspiracy theory
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ResearchWood microfluidics carve out a niche
Teflon-coated wood devices perform as well as plastic equivalents but face some challenges before they can realise their clinical and sustainable potential
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NewsConcerns raised over ‘regrettable’ BPA substitutions
Research indicates chemicals used as alternatives to bisphenol A in polycarbonate plastics and epoxy resins aren’t always safer
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NewsData manipulation casts shadows on Novartis gene therapy
Manufacturing problems with other new medicines highlight difficulty of developing advanced treatments
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OpinionMargaret Brimble: 'Spiroketals are my favourite molecules'
The New Zealand chemist on careers, creativity and why everything just has to be blue
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ArticleAccurate temperature control achieving big results, on a small scale
Radleys’ compact reaction station brings accurate temperature control to chemical scientists managing small-scale experiments
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OpinionAre new drugs better than existing ones?
Should companies be made to change the way they run clinical trials?
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ResearchModified metallohelices show medical potential
Post-assembly click reactions on helical metal complexes produces biological activity akin to that of the arrow poison ouabain
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ResearchCrispr treatment reverses muscular dystrophy in mice
Upregulated gene triggers laminin-α1 protein production, reviving paralysed limbs
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ArticleMultidisciplinary science kick starts innovation
Nanoform scientists discuss how their diverse personalities and scientific backgrounds foster innovation, helping them tackle problems from different angles, and design better processes
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ArticleThrough the looking glass: a digital future for healthcare
As the digital revolution continues to disrupt even the world’s most established business sectors, the pharmaceutical industry will need to shift and adapt if it is to realise its vision for the future of healthcare
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PodcastZinc polycarboxylate
Lay back in the chair and say 'Ahh', as Mike Freemantle introduces zinc polycarboxylate dental cement
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ResearchBacterial lasso gets to the heart of stem cell retention problem
A sticky bacterial protein on the surface of stem cells increases homing and retention on damaged heart tissue
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OpinionThe silent rise of the robots
Mechanical helpers have been creeping into our labs for decades
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PodcastCyclopropane
Chemistry’s tastiest bonds for an explosive anaesthetic that was as useful as it was dangerous
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ResearchPoly(ionic liquid)s respond like taste buds in new saccharide detection system
System that exploits non-covalent interactions between ionic liquid moieties and carbohydrates could have multiple real-world applications
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Podcast2C psychedelics
A class of hallucinogenic phenethylamines, explored by the 'godfather of psychedelics' Alexander Shulgin and sadly implicated in a tragedy at a 2017 music festival
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ResearchColourful antibiotics isolated from scorpion venom
Isolated benzoquinone has excellent activity against TB along with low toxicity in mice