Medicinal chemistry – Page 30
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ResearchDroplet screening set to accelerate immunotherapies into the clinic
Single-cell technique eliminates inefficiencies when identifying immune cells active against specific cancers
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ResearchCo-crystals fish out cannabinoid from plant extract
Purifying cannabidiol from natural cannabis extract made cheap and easy thanks to amino acid partner
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BusinessNurturing the next biotech generation
As incubator environments evolve, options for new companies looking for support are broadening
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ResearchNew family of peptides from extremophile show antibiotic promise
Scientists isolate salinipeptins from a bacterium living in America’s Dead Sea
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ArticleSmall particles making a big splash in clinical development
Nanoform is investigating how to tackle clinical attrition rates through nanonisation of APIs
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ArticleInvestigating multi-dimensional problems in drug substance development
Finding solutions to the biggest challenges faced during drug substance development relies on properly integrating analytical and production expertise
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ResearchHole-punching antifungal used as molecular prosthesis for cystic fibrosis
Drug creates artificial ion channels that could replace broken version in cystic fibrosis patients’ lung cells
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PodcastVinblastine and vincristine: Vinca alkaloids
Kat Arney unearths a story of an overlooked female researcher in the search for the origins of cancer drugs found in plants
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ResearchCopper mixes with alcohol abuse drug for anticancer action
Chemical model reveals how alcoholism drug disulfiram joins copper to kill cancer cells with oxidation overload
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ResearchSmall molecule finds flu virus’s weak spot
Drug candidate that targets highly conserved region of virus gave mice complete protection from swine flu
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FeatureThe battle to lose weight
Losing weight – and not putting it back on – is about much more than willpower. Nina Notman reports on the drugs trying to penetrate the complex metabolic web of hunger and satiety.
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ResearchCracking enzyme structure offers new way to treat rare heart diseases
Solution was found by combining protein with its chaperone
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BusinessSmartwound dressings spot infection early
Bacterial toxins burst dye-filled vesicles to give a visual warning
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NewsUniversity sues professor for taking graduate’s research that he stands to make millions from
University of Missouri–Kansas City pharmacy researcher accused of stealing inventions related to a novel eye drug delivery formulation, sold it for $1.5m plus royalties
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NewsGenome sequencing for healthy dismissed as waste of time for UK project
Personalised medicine plan unlikely to deliver any benefits for the wider population
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ResearchGenetically engineered yeast brews up heady mix of natural and unnatural cannabinoids
Biotech yeast makes low-cost, high-quality THC and CBD – and cannabinoids never seen before – without growing cannabis plants
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ResearchThe five reactions on every organic chemist’s wish list
Synthesis has some catching-up to do to create the reactions every drug discovery chemist dreams of
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FeaturePass the antidote
From paracetamol to pesticides – not to mention nerve agents – there are many toxic compounds that doctors need to be able to counteract. Nina Notman investigates
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ResearchTwo flavouring chemicals prevalent in e-cigarettes might harm lung function
Diacetyl and 2,3-pentanedione suppress gene expression related to cilia production and function