Medicinal chemistry – Page 31
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PodcastMelarsoprol
Cases of sleeping sickness – human African trypanosomiasis – are in decline, dropping 86% in Africa between 2000 and 2014. Gege Li explores the role that this toxic, arsenic-based medication has to play.
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NewsPersonalised medicine has failed to live up to the hype, researchers claim
Predictions that Human Genome Project would usher in an era of tailored therapies have largely failed to come true
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OpinionHow teenagers are disrupting drug discovery
A citizen science project to improve access to malaria drugs
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BusinessUK government sets out antimicrobial resistance plan
Aims to cut antibiotic use and explore financial incentives for pharmaceutical companies
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FeatureCan we live forever?
We are now living longer than ever before, but not always in perfect health. Anthony King talks to the researchers working to extend our healthspan
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PodcastCacodyl
It made Robert Bunsen seriously ill, Michael Faraday thought it 'barbaric' to use in battle and even Fritz Haber – the 'father of chemical warfare' – abandoned it after a fatal accident in his lab. This week, Mike Freemantle tells the story of tetramethyldiarsine, otherwise known as cacodyl.
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ResearchAlzheimer’s linked to infection of the brain by gum disease bacterium
Drug firm is developing treatment to inhibit bacterial enzymes believed to be damaging important protein
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ResearchScreening strategy pursues photocatalytic couplings for drug discovery
High-throughput screening and flow-based scale-up combo identifies chemistry needed to functionalise drug fragments and obtain useful amounts of product
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ResearchPatent-busting AI tool navigates around protected drug pathways
Organic retrosynthesis software can identify key bonds involved in patented reactions to find alternative pathways
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OpinionWhat are the rate-limiting steps in drug discovery?
Getting more drugs to market is not just a chemistry problem
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ResearchCrowdsourced drug discovery pits half-forgotten compounds against neglected diseases
45 research groups donate 350 compounds to the first crowdsourced screening library
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FeatureReady for a Raman shift
Raman spectroscopy has been seen as a tool for physicists and chemists but Hayley Bennett finds it has the potential to cause a major shift in the way we do medicine
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PodcastEllagic acid
Louise Crane introduces the antioxidant that led to exaggerated claims that 'whisky helps fight cancer'
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ResearchSelf-illuminating nanoparticles shine a light on cancer
Tumours trigger luminescence for imaging, then production of singlet oxygen to kill cancer cells
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ResearchBlood pressure drug reacts with membrane lipids
Lipidation products add to evidence that biological membranes are far from chemically inert
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ResearchNanodecoys lure and trap Zika virus
Gelatin nanoparticles camouflaged by mosquito membrane mop up virus and stop it crossing placenta
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ResearchPore-forming toxins detect long strands of DNA
Lithium electrolyte helps aerolysin overcome electrostatic obstacle to detect ssDNA longer than 100 nucleotides
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PodcastMyristicin
The spice that gives your Christmas eggnog its distinctive taste and aroma is also a toxic narcotic that played an important role in international history
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ResearchSelf-powered cancer therapy triple whammy
Diagnosis, drug delivery and effectiveness monitoring combination could realise precision cancer therapy
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ResearchDouble umpolung approach to amino amide synthesis
Unusual disconnection strategy behind stereocontrolled route to β-amino amides