Medicinal chemistry – Page 33
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ResearchNanopore sensors make breakthrough in monitoring health and disease
Biosensor simultaneously measures metabolite biomarkers in bodily fluids
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FeatureHow chemical evolution took the 2018 chemistry Nobel prize
Emma Stoye has the full story of how Frances Arnold, George Smith and Greg Winter put evolution to work in the lab
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OpinionThe projects drug companies wish they’d never started
Failures are common in drug research, but some are bigger than others
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ResearchNanoparticles offer extensive new cure for snakebites
Treatment neutralises venom, reducing tissue damage
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BusinessCleaning up clinical trials
Campaigns to enforce complete and correct reporting of trial data are beginning to take hold
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NewsWhat is directed evolution and why did it win the chemistry Nobel prize?
If you’ve got questions about yesterday’s chemistry Nobel prize then we’ve got answers
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NewsWhat is 'checkpoint therapy' and why did it win the medicine Nobel prize?
James Allison and Tasuku Honjo released the ‘brakes’ on our immune system to combat cancer
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NewsImmune-stimulating cancer treatment takes 2018 medicine Nobel
James Allison and Tasuku Honjo receive science’s highest honour for discovering how cancer stops immune cells from attacking
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ResearchHealthy animals mimic body odour of sick companions
Sniffer mice and chemical analysis suggest that sickness odours are contagious
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ResearchSimple test behind early cancer diagnosis breakthrough
Technique combines rolling circle amplification with time-gated Förster resonance energy transfer to detect cancer microRNA
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ResearchExotic amino acids made easy with radicals
Stereoselective radical coupling to rival classic Strecker synthesis for easy access to unusual amino acids
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BusinessLandmark China cancer drug full approval ‘first of a wave’
Chi-Med’s fruquintinib is a result of China’s evolving drug innovation and regulation
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FeatureThe nuclear option
Using radioisotopes to image inside patients’ bodies – nuclear medicine – is under threat from ageing reactors. James Mitchell Crow discovers the new science trying to fix the problem
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ResearchHepatitis C drug lead designed to target virus RNA
Gene-to-RNA-to-medicine pipeline possible thanks to technique that reveals interactions between RNA and small molecules
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NewsBitter feuding at Cochrane healthcare audit body paralyses organisation
One member has been expelled from the governing board while another four resign with accusations of pharmaceutical industry bias flying
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ResearchGenentech antibiotic quells resistance
Modified arylomycin combines high potency with new mechanism of action
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ResearchBlood markers link firefighters' lung disease to WTC attacks
Firefighters who developed lung disease after responding to 11 September attacks in New York connected to specific metabolic profile
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