Medicinal chemistry – Page 33
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ResearchCrowdsourced drug discovery pits half-forgotten compounds against neglected diseases
45 research groups donate 350 compounds to the first crowdsourced screening library
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FeatureReady for a Raman shift
Raman spectroscopy has been seen as a tool for physicists and chemists but Hayley Bennett finds it has the potential to cause a major shift in the way we do medicine
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PodcastEllagic acid
Louise Crane introduces the antioxidant that led to exaggerated claims that 'whisky helps fight cancer'
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ResearchSelf-illuminating nanoparticles shine a light on cancer
Tumours trigger luminescence for imaging, then production of singlet oxygen to kill cancer cells
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ResearchBlood pressure drug reacts with membrane lipids
Lipidation products add to evidence that biological membranes are far from chemically inert
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ResearchNanodecoys lure and trap Zika virus
Gelatin nanoparticles camouflaged by mosquito membrane mop up virus and stop it crossing placenta
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ResearchPore-forming toxins detect long strands of DNA
Lithium electrolyte helps aerolysin overcome electrostatic obstacle to detect ssDNA longer than 100 nucleotides
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PodcastMyristicin
The spice that gives your Christmas eggnog its distinctive taste and aroma is also a toxic narcotic that played an important role in international history
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ResearchSelf-powered cancer therapy triple whammy
Diagnosis, drug delivery and effectiveness monitoring combination could realise precision cancer therapy
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ResearchDouble umpolung approach to amino amide synthesis
Unusual disconnection strategy behind stereocontrolled route to β-amino amides
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ResearchFluorinated compounds in cosmetic products
Moisturisers, shaving foam and foundation investigated as sources of per- and polyfluoroalkyl substances
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ResearchErythropoietin benefits from controlled sugar-coating
Click chemistry allows glycosylation at virtually any synthetic stage
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BusinessSartan drug contamination brings cancer uncertainty
Levels of nitrosamines and other carcinogens in affected tablets of valsartan and related drugs similar to smoking 20 cigarettes a day
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NewsX-ray crystallographer to oversee Rosalind Franklin Institute
Structural biologist James Naismith to become first director of UK’s new national life sciences institute
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ResearchWearable sensor checks blood alcohol content using sweat
Device shows how sweat could be used as a non-invasive source of biochemical information
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BusinessBreaking the silence of RNA interference drugs
A wave of treatments is set to follow the first approval of an RNAi therapy
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ResearchScorpion venom peptide engineered to sting brain disorders
Structure used to escort nanoparticles across blood–brain barrier also resists protease degradation
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ReviewBitter Pills: The Global War on Counterfeit Drugs
Muhammad Zaman’s book gives an account of the challenges facing drug regulators worldwide
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BusinessTransforming PET imaging with silicon
Fuzionaire Diagnostics can add Si–18F radiolabels to a variety of molecules quickly, easily and cheaply
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ReviewHow to Change Your Mind: The New Science of Psychedelics
Journalist Michael Pollan’s 9th book is a fascinating history of psychedelic drugs.