Medicinal chemistry – Page 33
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ResearchBacterial lasso gets to the heart of stem cell retention problem
A sticky bacterial protein on the surface of stem cells increases homing and retention on damaged heart tissue
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OpinionThe silent rise of the robots
Mechanical helpers have been creeping into our labs for decades
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PodcastCyclopropane
Chemistry’s tastiest bonds for an explosive anaesthetic that was as useful as it was dangerous
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ResearchPoly(ionic liquid)s respond like taste buds in new saccharide detection system
System that exploits non-covalent interactions between ionic liquid moieties and carbohydrates could have multiple real-world applications
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Podcast2C psychedelics
A class of hallucinogenic phenethylamines, explored by the 'godfather of psychedelics' Alexander Shulgin and sadly implicated in a tragedy at a 2017 music festival
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ResearchColourful antibiotics isolated from scorpion venom
Isolated benzoquinone has excellent activity against TB along with low toxicity in mice
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NewsNorthwestern opens largest biomedical building of any US university
Chemistry sits atop Northwestern University’s new 12-story interdisciplinary biomedical centre
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PodcastAzidothymidine
The first drug approved in the US to treat Aids required a completely new approach to clinical trials – Frances Addison explores the history of azidothymidine
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ResearchGlucose-regulating nanogel keeps blood sugar in the sweet spot
System prevents hyperglycemia in rats by acting like an artificial liver
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OpinionIs this a golden age of new drug classes?
A host of new treatment modes are hitting the clinic and the market
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ResearchSaliva test uses surface imprinting to recognise Zika
Sensor matches surface roughness of its electrode with Zika’s dimensions and generates results within 20 minutes
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ResearchSpore shell acts as sunscreen for light-sensitive antibiotics
Polymer capsule that protects and preserves antimicrobial compound could aid fight against multi-drug resistant pathogens
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PodcastAmantadine
Katrina Krämer investigates how one of the smallest small molecule drugs around saved Jeanna Giese's life
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ResearchLaser technique watches how implants release drugs
Laser induced breakdown spectroscopy continues to diversify its applications
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WebinarMiniaturise the haystack: DNA-Encoded Libraries for drug discovery
A DNA-Encoded Library (DEL) case study and fragment-based DEL discovery insight from DyNAbind
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BusinessUS finalises guidance on biosimilars
Regulator clarifies requirements for allowing substitution between products
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ResearchTrefoil knots steer cancer drug leads in fresh direction
Chemists look to links and knots in the search for new cancer therapies
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FeatureChanging the locks
Designer receptors help understand cellular signals and could treat epilepsy and Parkinson’s disease, but need new tools, finds Andy Extance
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PodcastMethylphenidate (Ritalin)
Jamie Durrani diverts his attention to the rise of Ritalin, a drug first identified as a way of improving tennis performance
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