Medicinal chemistry – Page 35
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PodcastUnthinkable by Helen Thomson – Book club
Helen Thomson looks at some of the rarest neurological conditions known to science
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NewsWHO gears up to solve the world’s antivenom crisis
Clinical trials planned to take on scourge of substandard, untested medicines
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ResearchFour step route to carbotricycles
Elegant strategy that directly assembles 5–8–5 scaffolds from simple precursors paves way to a new library of bioactive compounds
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ResearchTool to navigate chemical space aims to be ‘Google Maps of drugs’
Software allows links between 8000 drugs and 47,000 compounds of environmental concern to be explored in 3D
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NewsNew life sciences institute wants to make drug discovery 10 times more efficient
The UK’s £103 million Rosalind Franklin Institute will unite robotics, chemistry and biophysics to generate drug candidates within weeks
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NewsVaccines central to efforts to head off latest Ebola outbreak
Ring vaccination strategy could halt disease in its tracks provided health systems can cope
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OpinionThe three muses of scientific discovery
Inspiration, experimentation and happy accidents are all pathways to a breakthrough
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NewsWhy antibiotic pollution is a global threat
Rising antibiotic resistance caused by pollutants needs action
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ResearchSurgical sensor tracks healing and then simply fades away
Exceptionally sensitive biodegradable implant can sense strain and pressure on recovering tendons
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ArticleAre polymer medicines viable therapeutics?
Combining small-molecule medicines with polymers could offer big rewards for pharmaceutical researchers
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ArticleThe dark side of chemical patents
Unloved, ignored and misunderstood but could all that change?
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FeatureUnderstanding Alzheimer’s
After hundreds of failed drug candidates, James Mitchell Crow asks if this is the last roll of the dice for the amyloid theory of Alzheimer’s disease
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PodcastCalcium hypochlorite
A component of 'trench atmosphere' and ‘the most powerful antiseptic known’, Mike Freemantle explores calcium hypochlorite and the birth of a chemical dynasty
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ResearchBrain chemistry hints at how obesity impairs antidepressants
Histamine released in response to obesity or bacterial toxins prevents benefits from SSRIs – and that drugs that target these inflammatory signals may restore them
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NewsBeetroot beats route to Alzheimer's
Betanin, the compound that gives beetroot it’s distinctive purple colour, may slow the process of protein misfolding that is linked to Alzheimer’s disease
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Feature3D printing in pharma
Nina Notman explores how 3D printing is carving out a niche for itself in the pharmaceutical industry
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OpinionWhy combination pills aren’t always the answer
The challenges of medicines containing multiple drugs aren’t going away
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PodcastTriamcinolone
Concluding our pair of podcasts on a recent cycling scandal, Ben Valsler looks at the corticosteroid triamcinolone