Medicinal chemistry – Page 35
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ResearchSimple test behind early cancer diagnosis breakthrough
Technique combines rolling circle amplification with time-gated Förster resonance energy transfer to detect cancer microRNA
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ResearchExotic amino acids made easy with radicals
Stereoselective radical coupling to rival classic Strecker synthesis for easy access to unusual amino acids
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BusinessLandmark China cancer drug full approval ‘first of a wave’
Chi-Med’s fruquintinib is a result of China’s evolving drug innovation and regulation
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FeatureThe nuclear option
Using radioisotopes to image inside patients’ bodies – nuclear medicine – is under threat from ageing reactors. James Mitchell Crow discovers the new science trying to fix the problem
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ResearchHepatitis C drug lead designed to target virus RNA
Gene-to-RNA-to-medicine pipeline possible thanks to technique that reveals interactions between RNA and small molecules
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NewsBitter feuding at Cochrane healthcare audit body paralyses organisation
One member has been expelled from the governing board while another four resign with accusations of pharmaceutical industry bias flying
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ResearchGenentech antibiotic quells resistance
Modified arylomycin combines high potency with new mechanism of action
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ResearchBlood markers link firefighters' lung disease to WTC attacks
Firefighters who developed lung disease after responding to 11 September attacks in New York connected to specific metabolic profile
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OpinionFeeding the confusion
When it comes to working out what foods do to our bodies, mostly we just don’t know
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FeatureThe quest to cure HIV
Although HIV–Aids can now be managed quite well with antiretroviral drugs, there is still no cure. Anthony King talks to the scientists trying to find one
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BusinessUS approves first RNA interference drug
Alnylam’s Onpattro (patisiran) can treat a rare hereditary disease by silencing a specific gene
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ResearchBismuth drugs kill bacteria by disrupting metabolism
Scientists throw kitchen sink of omics techniques at understanding complicated response of prevalent human pathogen to bismuth drug
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FeatureFrom folklore to pharmacy
Although many drugs have in the past come from plants, Hayley Bennett discovers that it’s hard work getting them approved today
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NewsEPA move could bring asbestos back in America
Health advocates fret at US environment agency’s proposal to make ‘new uses’ of asbestos-containing products legal, but EPA says not to worry
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PodcastThe Beautiful Cure by Daniel Davis – Book club
Immunologist Daniel Davis reveals the complexities of the human immune system
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ReviewThe Beautiful Cure: Harnessing your body's natural defences
The human body’s response to disease is fiendishly complex but endlessly fascinating
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