Medicinal chemistry – Page 37
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ResearchSurgical sensor tracks healing and then simply fades away
Exceptionally sensitive biodegradable implant can sense strain and pressure on recovering tendons
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ArticleAre polymer medicines viable therapeutics?
Combining small-molecule medicines with polymers could offer big rewards for pharmaceutical researchers
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ArticleThe dark side of chemical patents
Unloved, ignored and misunderstood but could all that change?
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FeatureUnderstanding Alzheimer’s
After hundreds of failed drug candidates, James Mitchell Crow asks if this is the last roll of the dice for the amyloid theory of Alzheimer’s disease
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PodcastCalcium hypochlorite
A component of 'trench atmosphere' and ‘the most powerful antiseptic known’, Mike Freemantle explores calcium hypochlorite and the birth of a chemical dynasty
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ResearchBrain chemistry hints at how obesity impairs antidepressants
Histamine released in response to obesity or bacterial toxins prevents benefits from SSRIs – and that drugs that target these inflammatory signals may restore them
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NewsBeetroot beats route to Alzheimer's
Betanin, the compound that gives beetroot it’s distinctive purple colour, may slow the process of protein misfolding that is linked to Alzheimer’s disease
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Feature3D printing in pharma
Nina Notman explores how 3D printing is carving out a niche for itself in the pharmaceutical industry
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OpinionWhy combination pills aren’t always the answer
The challenges of medicines containing multiple drugs aren’t going away
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PodcastTriamcinolone
Concluding our pair of podcasts on a recent cycling scandal, Ben Valsler looks at the corticosteroid triamcinolone
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ResearchNew theory for why lithium helps bipolar patients
Molecular insight could help researchers design mood stabilisers with fewer side effects
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NewsChemical weapons watchdog confirms UK’s nerve agent findings
Independent international investigators verify that a Novichok agent was used in attempted assassination of former Russian spy in Salisbury
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PodcastAcetylcysteine
How a versatile drug that helps manage lung conditions and treat paracetamol overdose found itself at the centre of a cycling scandal
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BusinessNovartis’ $8.7bn AveXis deal shows gene therapy appeal
Acquisition indicates the value of potentially permanent cures for inherited diseases
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ResearchArtificial blood reaches the feline frontier
Space crystals of serum proteins help scientists make a red blood cell substitute for cats
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ResearchJelly implant keeps an eye on body oxygen levels
A soft hydrogel implant – the first of which has survived in the foot of its inventor for four years – could detect circulatory problems that end in amputations
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ResearchSolving the crystal maze
Workflow swaps gut feelings for data when designing continuous crystallisation processes
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NewsGetting a better grasp of manganese to fight flu
A drug that can hold onto two metals atoms rather than just one becomes 1000 times more potent at knocking out a flu virus enzyme
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BusinessFit for repurpose
Drugs that can be used for new indications offer a potentially cheaper pathway – but only if the investors can recoup their costs