Medicinal chemistry – Page 42
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BusinessNovartis coasts towards first CAR-T approval
Unanimous recommendation for CTL019 ahead of October decision builds confidence in T-cell genetic reprogramming
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ResearchDietary supplement poisoning every 24 minutes in the US
275,000 calls concerning supplements were made to poison centres between 2002 and 2012
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Opinion(+)-Pleuromutilin
Total synthesis is sometimes the only way to explore the chemical space around a natural product
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ResearchSimplified structure eases antibiotic synthesis
New analogues of the potent antibiotic teixobactin could be instrumental in the fight against multi-drug resistant pathogens
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ResearchResponsive nanoparticles target sight-stealing fungus
Eye drop tricks fungal eye infection into self-destruction
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OpinionMaking enough of a difference
What if the needle in the drug development haystack ends up being too small to be useful?
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BusinessFDA approves first sickle cell drug in almost two decades
Glutamine-based drug is the first approved for children over 5
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BusinessAmplifying intelligent drug design
This year’s Chemistry World Entrepreneur of the year is Andrew Hopkins of start-up Exscientia and the University of Dundee, UK
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NewsEuropean ‘One Health’ plan aims to curb antimicrobial resistance
Action plan treats human and animal health as interconnected
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ResearchNew ingredients for edible electronics
Kitchen cupboard staples used in sensors for detecting digestive disorders
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ResearchBismuth drug structure solved
After over three centuries of mystery, the structure of bismuth subgallate has finally been uncovered
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ResearchLilly pushes continuous drug production limits
Integrated flow synthesis and purification process for prexasertib meets high industry standards
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PodcastCaesium chloride
A compound found in mineral water that is also used in medical treatments and solar cells
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ArticleSygnature Discovery
Sygnature Discovery is part of an innovative partnership to bolster the life science sector in Nottingham
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OpinionUnpicking a clinical trial death
A new study shows up off-target effects of a drug that proved deadly, and highlights the pitfalls of drug discovery
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FeatureAccess to drugs: a failure of pharma?
Many people around the world are either unable to afford the drugs they need, or their conditions have not been addressed by pharma R&D. Sarah Houlton investigates
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NewsAnalytical test strip fights fentanyl overdoses
Simple chemical analysis helps drug users prevent overdosing on deadly opioid
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ResearchModified antibiotic beats superbug resistance
Adding functional groups to vancomycin gives it extra modes of attack against resistant bacteria
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PodcastFibrin and fibrinogen
From scabby knees to life-threatening strokes, this important protein is the fundamental link in the complex molecular chain that forms blood clots
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OpinionDrug pricing must be more transparent
Pricing is a complex issue - how can we make it clearer?