Medicinal chemistry – Page 45
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FeatureNew MRI contrast agents
With rising concerns over gadolinium, Anthony King looks at the alternatives under development
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NewsPharma giants commit to tackling antimicrobial resistance
Plan to tackle superbugs includes changes to manufacturing and sales incentives
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PodcastFluorouracil
A substitute for one of the bases in DNA that can cause the death of cancer cells
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ResearchFreeze-dried cell parts for hassle-free molecule manufacturing
‘Just add water’ reaction pellets allow drugs and vaccines to be produced without special equipment or training
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ResearchGlowing polymer highlights mercury in fish
Portable fluorescent probe allows quick and easy detection of toxic pollutant
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OpinionSlimmer synthesis
Atom economy is a noble aim, but there are other routes to efficient molecule making
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BusinessDanaher boosts diagnostics with Cepheid buyout
$4bn deal strengthens Danaher’s life sciences portfolio
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BusinessFDA’s first Duchenne drug approval reveals schism
Oligonucleotide drug reaches market amid pressure from patient families and strife over ‘patient-focused drug development’ at the regulator
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NewsSerious shortage of medical isotopes predicted by year’s end
US National Academies warns that ‘severe’ shortages of molybdenum-99 and technetium-99m are likely
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PodcastErgotamine
Ben Valsler finds out why writing Alice’s adventures in Wonderland was such a headache for Lewis Carroll
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ResearchSynthesis strategy takes the pain out of finding malaria drugs
Compound libraries could help find treatments for a whole host of diseases
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BusinessJoined-up thinking
The rift between contract medicinal chemistry and chemical development needs to be bridged
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OpinionDon’t fear the Crispr
Does simple gene-editing mean the end of traditional medicinal chemistry? Probably not
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BusinessFDA urges labs to test all blood donations for Zika
Agency has also given emergency authorisation to two new Zika blood tests
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BusinessPfizer to buy Astrazeneca’s antibiotics
Deal tops up Pfizer’s late-stage development pipeline, but AZ will retain biological programmes
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OpinionHow to solve global health inequality
Our skills as scientists hold the answer, says the Bill & Melinda Gates Foundation
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OpinionPreparing for the future of pharma
Dave Allen discusses how scenario planning helps to define uncertainty in pharma
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ResearchMagnetic fields deliver cancer-killing bacteria to tumour’s heart
Guided microbes packed with drugs can reach the parts of cancers that other drugs just can’t reach
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