Medicinal chemistry – Page 46
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OpinionPutting chemistry back in biology
The chemical nature of biomolecular interactions can no longer be ignored
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ResearchDNA suitcases packed with gene therapy cargo
Nano-sized capsules can be unlocked to release drugs on demand
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PodcastGabapentin
Louise Crane documents the rise and fall of Gabapentin – from ‘wonder drug’ to illicit substance in just 50 years
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ResearchWhat's your nano poison?
Informatics tool helps researchers visualise complex toxicity datasets
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ResearchSepsis’ sticking point in for a shock
Simple microfluidic method helps detect life-threatening condition earlier
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BusinessLilly to buy Boehringer’s pet vaccines
Deal strengthens Lilly’s animal medicine division following recent acquisition
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ResearchConnectosomes smuggle drugs across membranes
Engineered vesicles could cut drug side-effects by delivering them straight into cells using cellular ‘airlocks’
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OpinionBooster shot
Zika and Ebola have highlighted the pharmaceutical industry’s ability to respond to critical needs
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FeatureDrugging the epigenome
Drugs that change how your genes are switched on or off could change how we treat many diseases, as Rachel Brazil discovers
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FeatureNew MRI contrast agents
With rising concerns over gadolinium, Anthony King looks at the alternatives under development
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NewsPharma giants commit to tackling antimicrobial resistance
Plan to tackle superbugs includes changes to manufacturing and sales incentives
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PodcastFluorouracil
A substitute for one of the bases in DNA that can cause the death of cancer cells
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ResearchFreeze-dried cell parts for hassle-free molecule manufacturing
‘Just add water’ reaction pellets allow drugs and vaccines to be produced without special equipment or training
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ResearchGlowing polymer highlights mercury in fish
Portable fluorescent probe allows quick and easy detection of toxic pollutant
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OpinionSlimmer synthesis
Atom economy is a noble aim, but there are other routes to efficient molecule making
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BusinessDanaher boosts diagnostics with Cepheid buyout
$4bn deal strengthens Danaher’s life sciences portfolio
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BusinessFDA’s first Duchenne drug approval reveals schism
Oligonucleotide drug reaches market amid pressure from patient families and strife over ‘patient-focused drug development’ at the regulator
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NewsSerious shortage of medical isotopes predicted by year’s end
US National Academies warns that ‘severe’ shortages of molybdenum-99 and technetium-99m are likely
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PodcastErgotamine
Ben Valsler finds out why writing Alice’s adventures in Wonderland was such a headache for Lewis Carroll