Medicinal chemistry – Page 51
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Research
Early lead exposure linked to sleep problems
Researchers find lead exposure in early childhood is associated with sleep difficulties later on
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BusinessAdvancing animal testing alternatives
Animal rights groups are engaging with researchers and regulators to develop replacement tests and ensure they’re adopted
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FeatureMolecule-making microbes
Extracting terpene drugs from plants is difficult and wasteful, so pharma companies are looking to biosynthesis, as Emiliano Feresin discovers
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BusinessViral cancer therapy approved in the US
T-Vec is the first approved oncolytic virus, but its limited treatment scope means it is unlikely to become a blockbuster
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ResearchEye drops show promise treating cataracts and even reversing damage
Sterol compound can ‘dissolve’ mis-folded proteins to help clear the lens offering hope to 100 million in developing world
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ResearchOral delivery of anticancer drug
Researchers endeavour to limit drug side effects and injections for cancer patients
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ResearchBiomarkers identify stroke victims with cognitive problems
A metabolomics approach to check whether a stroke has affected a patient’s memory or thinking processes
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NewsPoor diagnostics hinder battle against antibiotic resistance
Healthcare workers’ tools to diagnose infections remain stuck in the past
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NewsMalaria vaccine pilot studies recommended by WHO
GlaxoSmithKline’s RTS,S vaccine must undergo further testing before being rolled out, says World Health Organization panel
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ResearchTramadol found in African soils almost certainly artificial
New evidence may end speculation over plant production of painkiller first synthesised in the 1960s
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ResearchAdd more peroxide to stabilise new drug molecules
From a curiosity to life-saving medicine – how peroxides make for stable and efficient drugs
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ResearchCobalt could cut costs for pharma ingredients
Carboxylic acids and esters hydrogenated without the need for expensive precious metals
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PodcastCephalosporins
A story which starts knee-deep in sewage and ends with the spread of drug resistant infections like MRSA
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NewsCall for collaboration to take on resistance
Better partnerships across research, industry and policy are needed to tackle antimicrobial resistance, say research leaders
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NewsAntiparasitic drugs derived from natural products take 2015 medicine Nobel
Top science gong awarded for discovery and development of drugs that have improved the lives of millions
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PodcastA is for Arsenic by Kathryn Harkup – Book club
In the first of a brand new podcast series, we get together to discuss ‘A is for Arsenic: the poisons of Agatha Christie’
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OpinionSpice up your compounds
An occasional foray into uncharted territory is the hot sauce of medicinal chemistry, says Derek Lowe