Medicinal chemistry – Page 53
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PodcastChemistry World podcast – August 2015
In this space special, we learn how to study comets surfaces, and speak to a Nobel Prize winner about his 20-year-old prediction proving to be correct
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NewsMalaria vaccine approval first marred by efficacy question mark
Low protection rates in trials and uncertainty over cost-effectiveness leave vaccine’s future up in the air
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ResearchSingle polymer pill could deliver entire drug course in one go
Flexible elastomer ring springs open to stay in stomach and could slowly release drugs over days
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Research
Phthalate replacements linked to child health problems
Levels of two plasticisers in children found to correlate with higher blood pressure and insulin resistance
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News
Scientist imprisoned over fraudulent HIV vaccine research
Former Iowa State University researcher gets four-and-a-half years in prison for faking vaccine research funded by the NIH
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FeatureOrganic odysseys
Andy Extance looks at two drugs that cranked the synthetic challenge all the way up to Halaven
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NewsEPA under pressure over Enlist Duo herbicide
WHO has designated Enlist Duo’s two ingredients as a probable and possible human carcinogens
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News
NIH plan to get drug development unit back online
The US National Institutes of Health to address deficiencies in unit that makes drugs for research studies
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OpinionMissing the target
There are plenty of things that small molecule drugs can’t touch, says Derek Lowe, and it’s not for want of trying
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Research'Smart patch' set to deliver for diabetes patients
Stick-on patch with glucose responsive microneedles releases insulin automatically whenever it is needed
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News
Crowdsourcing compounds to tackle antibiotic resistance
A global screening project is searching for new antibiotics by asking chemists to send in novel compounds
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ResearchPromising compound offers single dose knock-out for malaria
Candidate antimalarial drug halt parasite protein synthesis and will enter human trials in a year
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ResearchRegulators have drug firms chasing phantom impurity
Mutagenic contaminants that supposedly form in sulfonic acid salts are highly unlikely to arise
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ResearchDrawing order from disorder to unravel Ebola’s lethality
Intrinsically disordered proteins may be vital in determining the deadliness of Ebola strains
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ResearchDNA inspires smart phospholipids
Liposomes made from synthetic nucleoside phospholipids could benefit drug delivery
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News
US spends billions annually on unreproducible preclinical research
Study estimates $28 billion spent yearly on preclinical research that can’t be replicated
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ResearchInjectable electronics unfold to monitor brain activity
Electronics a million times more flexible than the best currently available could transform patient monitoring
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ResearchMicrofluidic approach to personalised cancer treatment
Multiple myeloma drug response assay could be adapted for other cancers
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