Medicinal chemistry – Page 53
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ResearchHydrogel with a basic instinct for drug delivery
Gel that releases naproxen in alkaline surroundings is promising step toward relieving drug’s side effects
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ResearchSilicon chip spots dangerous pathogens in human blood
Silicon wafer doped with silver nanoparticles can rapidly identify E. coli in blood
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FeatureBig problems with little particles?
There is a risk that poor toxicology studies could start undermining the success of nanomaterials, reports Elinor Hughes
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ResearchDNA test colours in BRCA1 gene
Rolling circle amplification aids femtomolar sensitivity for gene linked with breast cancer
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FeatureCombating rare diseases
Developing drugs for treating rare diseases isn’t always financially viable. Clare Sansom looks at some recent success stories
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OpinionBe careful what you wish for
Measuring R&D productivity is a thorny issue. Dennis Lendrem urges the pharmaceutical industry to learn from its mistakes.
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OpinionAnalogues by catalogue
Buying in screening compounds directly feels like cutting out the synthetic chemist middleman, says Derek Lowe
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Business23andMe jumps into drug R&D
Gene profiling firm aims to capitalise on its databank of genetic information to discover new drugs
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FeatureIt's a bloody business
Determining the role drugs and poisons may have played in death is the responsibility of forensic toxicologists. Nina Notman reports
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ResearchProgram ready to weed out tough drug leads
Model could help drug firms avoid synthetically complex dead ends and speed drug discovery
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PodcastBarbituric acid
It may have been largely superceded in the clinic but Phil Robinson discovers there is no rest yet for barbituric acid
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ResearchSpicing up MOFs
Framework based on the turmeric pigment curcumin delivers two drugs for the price of one
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FeatureFrom screen to cell
Nina Notman finds out how liquid crystals are moving into the biotechnology and pharmaceutical toolbox
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Business
Europe approves stem cell therapy
Treatment for burn-damaged eyes uses patient’s own scaffold-grown cells
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OpinionTantalising technology
Computer-assisted drug design always looks like it’s just about to work, says Derek Lowe, but the reality is complicated
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OpinionA large life, fully lived
Carl Djerassi leaves many legacies besides the contraceptive pill,says Mark Peplow
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ResearchSilver lining for paper Ebola test
Lateral flow test checks for Ebola, yellow fever and dengue in one go