Medicinal chemistry – Page 54
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Research
Simple sensor can spot cancer markers in minutes
Test can rapidly detect mutant tumour nucleic acids in boost for personalised medicine
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OpinionMagic molecule modifiers
Late stage functionalisation can seem supernaturally powerful, says Derek Lowe – if you’ve got the nerve to try it
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ResearchTaking the lead on drug discovery
Making compounds that promise to become useful drugs has just become a little easier
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ResearchMalaria drug could cash in on green chemistry
Minimising acid and solvent toxicity brings surprising benefits in artemisinin production
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NewsRoadmap to reward pharma for creating new antibiotics unveiled
Report recommends large up-front payments and an innovation fund for blue skies research to tackle microbial resistance
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ReviewVenoms to drugs: venom as a source for the development of human therapeutics
Defanging chemistry
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NewsScientists call for ban on fluorinated chemicals
The Madrid Statement, signed by 200 scientists, urges consumers to avoid PFAS-containing products
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ResearchZombie cells may rise up to kill infections
Bacteria killed by silver may act as vessels for the metal to kill other pathogens
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FeatureImaging the future
Doctors and pharmaceutical companies are beginning to open their eyes to the power of mass spectrometry imaging, finds Nina Notman
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ResearchSiRNA treatment cures Ebola in monkeys
Researchers perform the first successful trial for a drug against the current strain of Ebola
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ResearchHydrogel with a basic instinct for drug delivery
Gel that releases naproxen in alkaline surroundings is promising step toward relieving drug’s side effects
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ResearchSilicon chip spots dangerous pathogens in human blood
Silicon wafer doped with silver nanoparticles can rapidly identify E. coli in blood
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FeatureBig problems with little particles?
There is a risk that poor toxicology studies could start undermining the success of nanomaterials, reports Elinor Hughes
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ResearchDNA test colours in BRCA1 gene
Rolling circle amplification aids femtomolar sensitivity for gene linked with breast cancer
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FeatureCombating rare diseases
Developing drugs for treating rare diseases isn’t always financially viable. Clare Sansom looks at some recent success stories
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Opinion'What gets measured gets done'
Measuring R&D productivity is a thorny issue. Dennis Lendrem urges the pharmaceutical industry to learn from its mistakes.
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OpinionAnalogues by catalogue
Buying in screening compounds directly feels like cutting out the synthetic chemist middleman, says Derek Lowe
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Business23andMe jumps into drug R&D
Gene profiling firm aims to capitalise on its databank of genetic information to discover new drugs
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FeatureIt's a bloody business
Determining the role drugs and poisons may have played in death is the responsibility of forensic toxicologists. Nina Notman reports