Molecular biology – Page 5
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FeatureHow Crispr went from niche to Nobel
Katrina Kramer tells the story of how Emmanuelle Charpentier and Jennifer Doudna developed the gene editing tool that won them the 2020 Nobel prize in chemistry
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NewsExplainer: What is Crispr and why did it win the Nobel prize?
The science behind the prize-winning gene editing tool that could change our lives
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FeatureUnnatural selection in chemical systems
Great strides have been made in the lab with chemical systems that ape life’s behaviour
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ResearchAntiaromaticity relief mechanism linked to DNA photostability
Textbook organic chemistry concepts bring new understanding to protective biological mechanisms
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ResearchProteins pinpointed in cells at nanometre resolution
Combining fluorescence microscopy and electron tomography will reveal more about how cells work and how diseases disrupt them
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ResearchProtein synthesis revolution on way as large peptides made in hours not days
Flow chemistry can now make peptide chains up to 164 amino acids long in one go
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ResearchTrapped enzyme reveals its unexpected shape-shifting ability
Metamorphic protein confined in nanopore found to switch between different 3D shapes as it catalyses a redox reaction
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NewsScience steps up a gear as struggle to both understand and fight coronavirus intensifies
Research that might have taken years is being turned around in months as journals fast-track Covid-19 manuscripts
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Research‘Chemical ear defenders’ could prevent hearing loss
Discovery of receptor connected to hearing loss has led to a chemical compound that can protect the neuromechanical machinery in mice’s ears
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ResearchFirst Crispr cancer trial in humans shows safety and durability
Immune-cell modifications target tumours and lift the PD-1 ‘brake’
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OpinionThe chemical absurdity of molecular recognition
Many biological models rely on an agency that molecules lack
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Feature
Can chemists crack our cells’ sugar code?
Rachel Brazil talks to the scientists trying to understand the sweet mystery of the glycome
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OpinionRichard Henderson: ‘I rejected the phone call, and then noticed it was from Sweden…’
The 2017 laureate tells his story
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OpinionChemical computers question the logic of life
Circuits of chemicals could carry out calculations
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OpinionEmbracing structural disorder
Medicinal chemists need to overcome their fear of fuzzy proteins
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ResearchCrispr treatment reverses muscular dystrophy in mice
Upregulated gene triggers laminin-α1 protein production, reviving paralysed limbs
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NewsInternational commission launched to tackle tough questions around gene-editing
US and UK scientific academies have convened a new body charged with developing a global framework for heritable human genome editing
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ResearchEnzyme evolved to selectively functionalise carbon–hydrogen bonds
Lactam libraries created by engineered bacterial enzyme offer new way to fight antibiotic resistance
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ResearchFirst bacterium with a totally redesigned genome created
Designer E. coli uses a simplified genetic code to make proteins
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ResearchTranscription controlled by non-natural DNA modifications
Proof-of-concept for artificial chemical epigenetics
