Natural products – Page 5
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OpinionNatural selection
Bioactive compounds don’t just inspire new synthetic strategies, they’re also the ultimate test
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Opinion(‒)-Pavidolide B
An innovative approach to making five-membered carbon rings makes for a strikingly short synthesis
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ResearchRoute to fiendishly complex marine molecule cut in half
Shortcut to promising natural product already in Alzheimer’s and HIV trials
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OpinionForcing fluorines into shape
Sometimes unnatural molecules can be more challenging to synthesise than natural metabolites
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ResearchSuper-electrophilic ions enable selective modification of bioactive molecules
New technique will help medicinal chemists explore chemical space
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OpinionThat’s stereochemistry
Recognising the tetrahedral nature of carbon changed science as well as explaining it
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ResearchStructural sleuthing salvages superbug slayer
Combining ‘assembly line’ synthesis, spectroscopy and computational predictions solves stereochemistry riddle
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Opinion(+)-Pleuromutilin
Total synthesis is sometimes the only way to explore the chemical space around a natural product
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ResearchSeductive sulfurs woo wasps
Amorous insect pollinators caught in the act with (methylthio)phenols
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NewsNews from the American Chemical Society meeting in San Francisco
News stories from the 253rd National Meeting & Exposition of the American Chemical Society
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ResearchMaple syrup enhances antibiotics
A phenol-rich mixture extracted from maple syrup allows much smaller doses of antibacterial drugs to achieve the same results
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Opinion(+)-Zincophorin methyl ester
New and old reactions combine for an elegant and concise synthesis
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ResearchTamed radicals expand chemical space
A method to functionalise complex molecules with catalytic radicals could expand chemical libraries of the drug and agrochemical industry
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ResearchReactive intermediates tamed in natural product synthesis
Benzynes perform remarkably selective reactions with natural products that lead to uniquely complex compounds
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ResearchRoadkill: new molecules at the side of the road
Wild animals run down on the roads can open surprising doors for opportunistic biochemists
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ResearchRoute to complex amines holds drug development promise
New catalytic reaction yields products with three adjacent chiral centres
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Research‘Ginger-meter’ tests strength of spice samples
Electrochemical sensor used to detect gingerol compounds
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ResearchRing-locking holds the key to levoglucosan production
Functionalising sugars could help to unlock the potential of biomass in chemical synthesis