Designer protein performs multi-step catalysis with life-like performance
By 
Victoria Atkinson2025-02-25T09:30:00
Computer-designed enzyme competitive with nature for the first time
A synthetic hydrolase enzyme with activity comparable to natural proteins has been designed from scratch using a combination of generative AI techniques. Synthetic proteins that promote multi-step catalysis have previously proven challenging to engineer. But the team behind this work, led by 2024 Nobel prize winner David Baker, believe that their approach will enable the design of new enzymes capable of performing a range of complex transformations.