Skeletal editing provides quick access to pharmaceutical ‘matching pairs’
By 
Victoria Atkinson2025-05-09T11:53:00
Late-stage functional group switching in dibenzofurans will aid drug discovery chemistry
An alternative use for skeletal editing provides a one-pot method to synthesise ‘matching pairs’ of pharmaceutical candidates for structure-activity relationship (SAR) studies. This functional group transposition employs a photochemical reaction to exchange two ring carbons in dihydrobenzofuran substrates, simultaneously switching the position of any associated functional groups to produce the constitutional isomer.