Organic chemistry
The latest chemistry news and research on organic chemistry, including synthesis, natural products and total synthesis, reaction mechanisms and supramolecular chemistry, from the Royal Society of Chemistry's magazine, Chemistry World
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Research
Large language models are better than humans at answering chemistry questions
AI models outperform human chemists in every topic area. But are they really better chemists?
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Research
AI robots work together to perform autonomous synthesis and analysis
System offers route for rapid testing, analysis and interpretation of a wide range of chemistries
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Research
Synthetic strategies overcome Bredt’s rule, unlocking complex bridgehead alkenes
Two research groups propose new synthetic strategies for making ‘impossible’ molecules, defying a 100-year-old bonding rule
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Research
Cyclopropyl effect causes substituents on cyclohexane to favour axial conformation
‘Unusual stereocontrol element’ will help medicinal chemists increase three-dimensionality of drug candidates
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Research
Carbon capture COF shows impressive ability to survive hundreds of cycles
Fast take-up and low regeneration temperatures make direct air capture promising
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Research
New catalytic strategies boost alkene synthesis
Photocatalyst makes complex alkenes from acids, alkanes or alcohols, while a ‘phase-pure’ iron catalyst reduces unwanted Fischer–Tropsch waste products
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Research
Skeletal editing technique removes nitrogen atoms from rotaxanes
Reaction breaks and repairs a rotaxane’s axle without allowing its ring to slide off
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Research
Microbubbles activate C–H bonds, converting methane into ethane and formic acid
Inside-out microdroplets induce oxidation reaction
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News
Perseverance rover’s discovery of organics on Mars could be illusory
Hopes that compounds were sign of prebiotic chemistry or even ancient life may be result of instrument limitations
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Research
New database unlocks predictive power of radical polarity
Resource could help reduce trial and error in synthesis
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Research
Atom-swapping reaction turns furans into pyrroles
Skeletal-editing technique offers easy way to modify heterocyclic structures
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Research
Photoswitch brings energy storage and a cool efficiency boost to photovoltaics
Energy harvesting molecules can halt heating that hits solar cells’ efficiency while storing energy
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Research
A new gold standard in selective nitrobenzene hydrogenation
Reaction proceeds through a previously unidentified mechanism
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Research
Quantum tunnelling explains why several supposedly stable benzene isomers will never be made
Research highlights importance of considering quantum effects in computational studies on strained molecules
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Research
One-electron covalent bond between two carbons pushes limits of bonding
Linus Pauling proposed exotic bonds but they have never been seen between two carbons until now
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News
The refugee organic chemist
After a harrowing journey from his native Afghanistan one refugee chemist has found safety in a postdoc position in the UK
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Opinion
A chemist in the flower garden
The beautifully complex molecules plants produce are as inspiring as the blooms themselves
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Research
PFAS-free synthesis of fluorinated drugs and pesticides
Flow chemistry introduces trifluoromethyl group onto a range of compounds using just caesium fluoride as the fluorine source