Organic chemistry – Page 16
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FeatureComputer-guided retrosynthesis
Machine learning-based systems hope to outperform expert-guided reaction planning technology, finds Andy Extance
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ResearchUncovering new transformations by using electricity as a reagent
Song Lin explains the power of electrochemistry and how he fosters an inclusive environment for his research group
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ResearchRe-evaluating pyridine’s role in chlorination reaction
Well-established mechanism for chlorination using dichloroiodobenzene together with pyridine proven wrong
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OpinionExploring the potential of nanoarchitectonics
Combining self-assembly techniques from across scientific disciplines could allow us to precisely build any material structure
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ResearchPeptide ligation strategy unlocks diverse range of structural motifs
Approach expected to influence design of protein–protein interaction inhibitors
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ResearchNitrogen deletion reaction offers ‘new way to think about molecular editing’
Reagent inspired by decades-old research could save chemists a lot of headache when it comes to modifying molecules’ skeleton
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ResearchAutomated organic synthesis made easier with capsule-based console
Integrated console to synthesise drug-like molecules requires minimal user input
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ResearchAlkali cations boost carbon dioxide reduction into feedstock chemical
Discovery enables continuous-flow electrolysers with industrial potential
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ResearchAI enantioselectivity predictor set to power computational catalyst screening
Workflow involves mapping a reaction representation onto the activation energy of the stereocontrolling step
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ResearchRapidly alternating polarity stars in selective electrochemical reduction
Rapidly fluctuating AC targets specific carbonyl groups in the presence of several reducible groups
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NewsBots bring chemistry research tools to Twitter
Cheminformatic tool can deliver retrosynthetic analysis
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ResearchTri-agonist molecule designed to stimulate immune system crosstalk
Conjugation chemistry connects three different agonists around a triazine core
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ResearchAdding constraints to understand life’s chemical origins
Matt Powner wants to know if there are chemical rules that govern why certain synthetic strategies are embedded in biology
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ResearchChemists reconsider the impact of through-space effects
Through-space electrostatic effects are shown to be dominant in certain radical reactions, where previously through-bond interactions were thought to determine reaction rate
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ResearchSupramolecular cage unlocks mild aldehyde reduction strategy
Computational analysis reveals how encapsulation stabilises protonated oxocarbenium ion of furfural, which makes the carbonyl moiety easier to reduce
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OpinionThe active uses of an inert gas
Meeting the many demands for nitrogen in chemical plants requires a fascinating piece of equipment
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ResearchPlasmon-assisted click reaction reverses typical relationship between temperature and rate
Decrease in temperature seems to extend lifetime of plasma-induced excited states, which increases probability of reaction occurring
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ResearchProgrammed cyclodextrin synthesis picks out specific molecule from 117,655 possibilities
Thioacetate orienting group allows for fine-tuned cyclodextrin functionalisation
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OpinionFive lessons from the career journey of an accidental chemist
Tip and tricks from dilutions to the excellent properties of lab floors