Organic chemistry – Page 2
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ResearchCascade reaction brings a new dimension to amine synthesis
Method creates two new rings and four new bonds
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ResearchCatenane with tuneable mechanical chirality created
The chirality of a compact cationic catenane can be controlled using chiral sulfonate anions
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ResearchReimagining synthetic strategy with skeletal editing ticks box on chemists’ wish list
Selective heteroatom alkylation offers route to modify important drug building blocks
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ResearchLight-activated catalyst sorts mirror-image molecules by resetting carbon–halogen bonds
Photocatalytic reaction that inverts chiral centres offers new way to enrich racemic mixtures
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Research‘Bowtie-shaped’ molecule displays spin entanglement
A new solution synthesis strategy could catapult quantum applications
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ResearchSpray-drying investigated as a speedy method for synthesising small organic molecules
Technique applied to Schiff-base condensations, Claisen–Schmidt reactions and amine acylations
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ResearchLong-chain alkanes preserved in Martian mudstone
Molecules could have derived from biological fatty acids, although abiotic origins are also possible
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ResearchSkeletal editing targets double bonds
Two new techniques selectively install nitrogen atoms into complex molecules
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ResearchStudy challenges notion that solution-phase organic reactions are unfeasible at high temperatures
Capillary synthesis at 500°C converts N-substituted pyrazoles into their isomers within five minutes
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ResearchUnusual radical reaction powered by strained substrates
Single-electron strain-release produces pharmaceutical building blocks
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ResearchForbidden electrocyclic reactions can be more allowed than previously thought
Study suggests such reactions should instead be described as either ‘Woodward–Hoffmann favoured’ or ‘Woodward–Hoffmann disfavoured’
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ResearchTotal synthesis of anti-addictive alkaloid in just seven steps
A streamlined synthesis of the psychoactive compound ibogaine could open up new opportunities in the treatment of drug addiction and depression
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FeatureMelanie Sanford’s route from college gymnast to groundbreaking researcher
One-time gymnast Melanie Sanford has made a name for herself in catalysis and organometallic chemistry. Rebecca Trager charts her path to success, from her mentors to her mentoring
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OpinionFluorine makes you an offer you can’t refuse
What might we do if we had a new, electron-donating equivalent element?
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Opinion(–)-Scabrolide B (again!)
Proverbially, comparison may not bring joy – but it can be educational
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ResearchSimulations suggest why highly unsaturated molecules are so abundant in the interstellar medium
Shocks, cosmic rays and x-rays seem to ionise and fragment saturated molecules via mechanisms that result in structures with the highest possible number of π bonds
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OpinionRobots queuing up to fail
Claims of an AI revolution in drug discovery are missing the biggest problem
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OpinionThe right level of trust in the scientific literature
An overreliance on what’s gone before can hinder innovation
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ResearchWireless, light-powered device opens door to high-throughput electrosynthesis
‘Ingenious and creative solution’ to electrochemistry’s ‘horrible wiring problem’
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ResearchShape-shifting carbon ring helps researchers test alternative weed management tactic
Pausing plant growth, rather than completely inhibiting it, might make weeds less inclined to develop resistance