Organic chemistry – Page 24
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OpinionStille cross-coupling
Palladium and tin combined to lay the foundations for a revolution in C–C bond-forming reactions
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ResearchFirst synthesis of unusual natural product could revive forgotten eco-friendly insecticide class
16-step synthesis of rare diterpene could reveal new ways to control insecticide-resistant pests
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ResearchTemplate molecules round-up extra-large cyclodextrins from enzymatic synthesis
Scientists rethink how they use enzymes in chemical synthesis by exerting thermodynamic, rather than kinetic, control
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ResearchUniversal method bypasses obstacles to making neglected hydrocarbon skeletons
Universal method bypasses obstacles to making neglected hydrocarbon skeletons
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OpinionEmbracing structural disorder
Medicinal chemists need to overcome their fear of fuzzy proteins
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ResearchHuman biases cause problems for machines trying to learn chemistry
Including ‘unpopular’ reagents and reaction conditions into datasets could lead to better machine-learning models
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OpinionStereoselectivity with a twist
Helical ligands amplify solvent chirality to control reaction outcomes
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ResearchSolution to 120 year-old puzzle reveals new chemical phenomenon
Seemingly identical acetaldehyde phenylhydrazone crystals melt at different temperatures
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ResearchGiant tree molecule made out of 45 rotaxanes switches size on demand
Mechanically interlocked molecules give dendrimer the ability to expand and contract
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ResearchNew carbodiphosphoranes break superbasicity record
Chemists overcome synthetic challenges to make uncharged carbon molecules that sit at far end of THF basicity scale
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ResearchCatalyst cleans up alcohol couplings
Eight years’ work yields Mitsunobu chemistry with nothing but water as a byproduct
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ResearchCarbon dioxide serves as carbonyl source in frugal process for making aromatic esters
Nanoscale confinement triggers strong base reactivity in process that shuns stoichiometric consumption of resource intensive reagents
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ResearchRetrosynthetic algorithm broadened to design similar, but different, molecules
Chematica can now design efficient syntheses for large compound libraries
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ResearchFirst ever synthesis of most double-bond-rich hydrocarbon
Tiny hydrocarbon with six double bonds has unrivalled ability to make complex ring systems though multiple Diels–Alder reactions
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ResearchExplosive 25% more powerful than TNT found in first study of energetic isomers
Stereo- and regiochemistry affect compounds’ explosive potential
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ResearchNew form of pure carbon made by manipulating atoms
Elusive 18-carbon ring pinned down on surface
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OpinionMargaret Brimble: 'Spiroketals are my favourite molecules'
The New Zealand chemist on careers, creativity and why everything just has to be blue
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ArticleAccurate temperature control achieving big results, on a small scale
Radleys’ compact reaction station brings accurate temperature control to chemical scientists managing small-scale experiments
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ResearchPush–pull radical theory finally vindicated after decades of back and forth
Solvent effect proves that captodative effect really exists after all
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ResearchModified metallohelices show medical potential
Post-assembly click reactions on helical metal complexes produces biological activity akin to that of the arrow poison ouabain